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connexin43
Connexin-43
Connexin-43 (Cx43, gene GJA1) — primary gap junction protein of ventricular myocardium. Hexameric connexons dock end-to-end at intercalated discs forming ~1.4 nS pores, making the myocardium an electrical syncytium for coordinated contraction.
Entry Metadata
| Field | Value |
|---|---|
| ID | connexin43 |
| Name | Connexin-43 |
| Status | draft |
| Last reviewed | 2026-06-03 |
| Atlas | 01-human |
| Scale | 03-molecular |
| Uniprot | P17302 |
| Gene Symbol | GJA1 |
| Chromosome | 6q22.31 |
Cross-Atlas Connections
Sources
- Severs NJ, Bruce AF, Dupont E, Rothery S. Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res. 2008;80(1):9-19. · PubMed 18519446
- Saffitz JE, Kanter HL, Green KG, Tolley TK, Beyer EC. Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ Res. 1994;74(6):1065-70. · PubMed 8187276
- Evans WH, Martin PE. Gap junctions: structure and function. Mol Membr Biol. 2002;19(2):121-36. · PubMed 12126230
- Rohr S. Role of gap junctions in the propagation of the cardiac action potential. Cardiovasc Res. 2004;62(2):309-22. · PubMed 15094351