Atlas One · Host Biology · Scale 07 — System

Heart Failure

Syndrome of impaired cardiac output inadequate for tissue metabolic demands. HFrEF (EF<40%), HFmrEF (40-49%), HFpEF (≥50%). ~64 million affected. GDMT: ACE-I/ARBs, beta-blockers, MRA, SGLT2i, ARNI (sacubitril-valsartan).

Also known as: heart failure, HF, congestive heart failure, CHF, HFrEF, HFpEF, cardiac failure

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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heart-failure

Heart Failure

Syndrome of impaired cardiac output inadequate for tissue metabolic demands. HFrEF (EF<40%), HFmrEF (40-49%), HFpEF (≥50%). ~64 million affected. GDMT: ACE-I/ARBs, beta-blockers, MRA, SGLT2i, ARNI (sacubitril-valsartan).

Entry Metadata

FieldValue
IDheart-failure
NameHeart Failure
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

part-ofHeart modulated-byAngiotensin Ii modulated-byAldosterone containsCardiomyocyte connects-toPcsk9 connects-toSglt2 connects-toFgf23 connects-toBnp connects-toGalectin 3 connects-toIl 33 connects-toPeriostin connects-toConnexin43 connects-toPhospholamban connects-toHcn4 connects-toRyr2 connects-toTroponin Complex connects-toNcx1

Sources