Atlas One · Host Biology · Scale 07 — System

Heart Failure

Syndrome of impaired cardiac output inadequate for tissue metabolic demands. HFrEF (EF<40%), HFmrEF (40-49%), HFpEF (≥50%). ~64 million affected. GDMT: ACE-I/ARBs, beta-blockers, MRA, SGLT2i, ARNI (sacubitril-valsartan).

Also known as: heart failure, HF, congestive heart failure, CHF, HFrEF, HFpEF, cardiac failure

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
heart-failure

Heart Failure

Syndrome of impaired cardiac output inadequate for tissue metabolic demands. HFrEF (EF<40%), HFmrEF (40-49%), HFpEF (≥50%). ~64 million affected. GDMT: ACE-I/ARBs, beta-blockers, MRA, SGLT2i, ARNI (sacubitril-valsartan).

Entry Metadata

FieldValue
IDheart-failure
NameHeart Failure
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

part-ofHeart modulated-byAngiotensin Ii modulated-byAldosterone containsCardiomyocyte connects-toPcsk9 connects-toSglt2 connects-toFgf23 connects-toBnp connects-toGalectin 3 connects-toIl 33 connects-toPeriostin connects-toConnexin43 connects-toPhospholamban connects-toHcn4 connects-toRyr2 connects-toTroponin Complex connects-toNcx1 connects-toKidney connects-toHypertension connects-toCardiovascular System connects-toAtherosclerosis connects-toFibrosis connects-toLung connects-toIron connects-toObesity connects-toNorepinephrine connects-toCalcium connects-toAtp connects-toMacrophage connects-toSodium connects-toLiver connects-toFibroblast connects-toPhoton connects-toEndothelial Cell connects-toPotassium connects-toElectron connects-toMagnesium connects-toErythrocyte connects-toThyroid connects-toAlbumin connects-toVasopressin connects-toAntibody connects-toNeuron connects-toReproductive System connects-toRenin connects-toCkd connects-toStroke connects-toType 2 Diabetes connects-toBradykinin connects-toVegf connects-toNf Kb connects-toVenous Thromboembolism connects-toAnemia Of Chronic Disease connects-toPulmonary Arterial Hypertension connects-toGout connects-toMajor Depressive Disorder connects-toAlzheimers Disease connects-toNash connects-toSepsis connects-toIron Deficiency Anemia connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toRenal System connects-toEndocrine System connects-toMusculoskeletal System connects-toNervous System connects-toImmune System connects-toAce Inhibitors connects-toBeta Blockers connects-toLoop Diuretics connects-toArbs connects-toMyocardium connects-toCardiac Conduction System connects-toAlveolus connects-toGlomerulus connects-toMultiple Myeloma connects-toCopd connects-toArterial Wall connects-toBone Marrow connects-toTrypanosoma Cruzi connects-toBreast Cancer connects-toEndocardium connects-toEndothelin 1 connects-toTnf Alpha connects-toAdiponectin connects-toIl 6 connects-toNlrp3 Inflammasome connects-toMtor connects-toSerca2A connects-toBeta1 Adrenergic Receptor connects-toMyostatin connects-toHepcidin connects-toNitric Oxide connects-toGlp 1 connects-toCalcineurin connects-toTgf Beta connects-toErk1 2 connects-toAkt connects-toNfe2L2 connects-toCaspase 3 connects-toTlr4 connects-toJak1 2 connects-toHif 1Alpha connects-toSmad4 connects-toStat3 connects-toCgas Sting connects-toFoxo connects-toGsk 3B connects-toStat1 connects-toPik3Ca connects-toS100A8 A9 connects-toPerforin connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toIl 1B connects-toCxcl12 connects-toIl 17A connects-toArid1A connects-toThyroid Hormones connects-toInsulin connects-toXanthine Oxidase connects-toHemoglobin connects-toEstrogen connects-toCovid 19 Disease connects-toCholesterol connects-toIl 10 connects-toLeptin connects-toIl 4 connects-toProstaglandins connects-toAngiopoietin connects-toIl 13 connects-toResistin connects-toOxygen connects-toType 2 Diabetes connects-toSodium connects-toMacrophage connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toMast Cell connects-toDendritic Cell connects-toComplement C3 connects-toC5Ar1 connects-toTransferrin connects-toTslp connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toHistamine connects-toComplement C5 connects-toFactor H connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toProlactin connects-toSelenium connects-toZinc connects-toCopper connects-toIodine connects-toPhosphorus connects-toNitrogen connects-toChloride connects-toCarbon connects-toHydrogen connects-toSulfur connects-toPd 1 connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toNotch connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAndrogen Receptor connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toCortisol connects-toGhrelin

Sources