Atlas One · Host Biology · Scale 03 — Molecular

cGAS-STING

cGAS (cyclic GMP-AMP synthase; MB21D1) senses cytosolic dsDNA → cGAMP → STING → TBK1 → IRF3 → IFN-β + NF-κB → inflammatory cytokines; activated by mtDNA, viral DNA, NETs; cGAS-STING drives interferonopathies (SLE, AGS); STING agonists (ADU-S100) activate anti-tumor immunity.

Also known as: cGAS, STING, cyclic GMP-AMP synthase, MB21D1, TMEM173, cGAMP, cyclic dinucleotide, innate DNA sensor, interferonopathy, cytosolic DNA sensing, SAVI, ADU-S100, TBK1-IRF3 axis

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
cgas-sting

cGAS-STING

cGAS (cyclic GMP-AMP synthase; MB21D1) senses cytosolic dsDNA → cGAMP → STING → TBK1 → IRF3 → IFN-β + NF-κB → inflammatory cytokines; activated by mtDNA, viral DNA, NETs; cGAS-STING drives interferonopathies (SLE, AGS); STING agonists (ADU-S100) activate anti-tumor immunity.

Entry Metadata

FieldValue
IDcgas-sting
NamecGAS-STING
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toAicardi Goutieres Syndrome connects-toSystemic Lupus Erythematosus connects-toType I Interferon connects-toNf Kb

Sources