Atlas One · Host Biology · Scale 03 — Molecular

Type I Interferon

IFN-α/β (type I IFNs) are antiviral cytokines; cGAS-STING or RIG-I/MDA5 → TBK1 → IRF3/7 → IFN-α/β → IFNAR1/2 → JAK1/TYK2 → STAT1/STAT2 → ISGs. Type I IFN signature drives SLE, SSc, dermatomyositis; anifrolumab (anti-IFNAR1) approved for SLE.

Also known as: type I interferon, IFN-alpha, IFN-beta, IFN-α, IFN-β, IFNA, IFNB, type I IFN, interferon alpha, interferon beta, innate antiviral, cGAS-STING, RIG-I, MDA5, MAVS, ISG, interferon-stimulated gene, anifrolumab, IFNAR1, IFNAR2, IFN signature

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
type-i-interferon

Type I Interferon

IFN-α/β (type I IFNs) are antiviral cytokines; cGAS-STING or RIG-I/MDA5 → TBK1 → IRF3/7 → IFN-α/β → IFNAR1/2 → JAK1/TYK2 → STAT1/STAT2 → ISGs. Type I IFN signature drives SLE, SSc, dermatomyositis; anifrolumab (anti-IFNAR1) approved for SLE.

Entry Metadata

FieldValue
IDtype-i-interferon
NameType I Interferon
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toSystemic Lupus Erythematosus connects-toSystemic Sclerosis connects-toSars Cov 2 connects-toNf Kb

Sources