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systemic-sclerosis
Systemic Sclerosis
Systemic sclerosis (SSc) is an autoimmune CTD with vasculopathy (Raynaud's), autoantibodies (anti-Scl-70, anti-centromere, anti-RNA pol III), and progressive fibrosis of skin and viscera; limited (lcSSc) vs. diffuse (dcSSc); ILD and PAH are leading causes of death.
Entry Metadata
| Field | Value |
|---|---|
| ID | systemic-sclerosis |
| Name | Systemic Sclerosis |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Denton CP, Khanna D. Systemic sclerosis. Lancet. 2017;390(10103):1685-1699. · PubMed 28413064
- Distler O, Highland KB, Gahlemann M, et al. Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease. N Engl J Med. 2019;380(26):2518-2528. · PubMed 31112379
- Khanna D, Denton CP, Jahreis A, et al. Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial. Lancet. 2016;387(10038):2630-2640. · PubMed 27156007