Atlas One · Host Biology · Scale 07 — System

Systemic Sclerosis

Systemic sclerosis (SSc) is an autoimmune CTD with vasculopathy (Raynaud's), autoantibodies (anti-Scl-70, anti-centromere, anti-RNA pol III), and progressive fibrosis of skin and viscera; limited (lcSSc) vs. diffuse (dcSSc); ILD and PAH are leading causes of death.

Also known as: SSc, scleroderma, systemic scleroderma, diffuse cutaneous systemic sclerosis, dcSSc, limited cutaneous systemic sclerosis, lcSSc, CREST syndrome, anti-Scl-70, anti-centromere antibody, SSc-ILD, SSc-PAH, scleroderma renal crisis

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
systemic-sclerosis

Systemic Sclerosis

Systemic sclerosis (SSc) is an autoimmune CTD with vasculopathy (Raynaud's), autoantibodies (anti-Scl-70, anti-centromere, anti-RNA pol III), and progressive fibrosis of skin and viscera; limited (lcSSc) vs. diffuse (dcSSc); ILD and PAH are leading causes of death.

Entry Metadata

FieldValue
IDsystemic-sclerosis
NameSystemic Sclerosis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toTgf Beta connects-toPulmonary Arterial Hypertension connects-toIl 6 connects-toType I Interferon connects-toSkin connects-toFibroblast connects-toKidney connects-toSjogrens Syndrome connects-toLung connects-toEndothelial Cell connects-toSystemic Lupus Erythematosus connects-toDermatomyositis connects-toDigestive System connects-toRheumatoid Arthritis connects-toCollagen connects-toSmooth Muscle Cell connects-toFibrosis connects-toHeart connects-toEndothelin 1 connects-toImmune System connects-toB Cell connects-toT Helper Cell connects-toAngiotensin Ii connects-toCalcium connects-toNitric Oxide connects-toPdgf connects-toMacrophage connects-toMast Cell connects-toLarge Intestine connects-toDendritic Cell connects-toOxygen connects-toHydrogen connects-toStomach connects-toBone Marrow connects-toPhoton connects-toLiver connects-toPlatelet connects-toAntibody connects-toSmall Intestine connects-toErythrocyte connects-toReproductive System connects-toPeripheral Nerve connects-toVitamin D connects-toWnt Beta Catenin connects-toRegulatory T Cell connects-toThyroid connects-toIl 13 connects-toCardiomyocyte connects-toCkd connects-toStat3 connects-toVenous Thromboembolism connects-toSepsis connects-toCandida Albicans connects-toHeart Failure connects-toAnemia Of Chronic Disease connects-toStroke connects-toAspergillus Fumigatus connects-toMajor Depressive Disorder connects-toIntegumentary System connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toRenal System connects-toMusculoskeletal System connects-toCardiovascular System connects-toNervous System connects-toEndocrine System connects-toAce Inhibitors connects-toCalcium Channel Blockers connects-toCorticosteroids connects-toCancer Chemotherapy connects-toTargeted Therapy connects-toArterial Wall connects-toMyocardium connects-toGlomerulus connects-toThrombotic Thrombocytopenic Purpura connects-toAlveolus connects-toCortical Bone connects-toGvhd connects-toEsophageal Cancer connects-toBreast Cancer connects-toCardiac Conduction System connects-toVegf connects-toIl 4 connects-toAnca Vasculitis connects-toCcl2 connects-toIl 17A connects-toHif 1Alpha connects-toCd20 connects-toJak1 2 connects-toSerotonin connects-toPeriostin connects-toAngiopoietin connects-toIl 33 connects-toSmad4 connects-toPf4 connects-toBaff connects-toErk1 2 connects-toMtor connects-toMyd88 connects-toNf Kb connects-toNfe2L2 connects-toAkt connects-toGalectin 3 connects-toStat1 connects-toPten connects-toCgas Sting connects-toFoxo connects-toGsk 3B connects-toS100A8 A9 connects-toPerforin connects-toCdk4 6 connects-toPik3Ca connects-toSrc Kinase connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 1B connects-toComplement C3 connects-toImmunoglobulin G connects-toProstaglandins connects-toBnp connects-toHemoglobin connects-toTroponin Complex connects-toMhc Class Ii connects-toAdamts13 connects-toXanthine Oxidase connects-toIl 10 connects-toIron connects-toHistamine connects-toRenin connects-toHepcidin connects-toVon Willebrand Factor connects-toAdiponectin connects-toLeptin connects-toResistin connects-toZinc connects-toPlasma Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toTslp connects-toC5Ar1 connects-toIl 31 connects-toComplement C5 connects-toFactor H connects-toT Cytotoxic Cell connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toMelatonin connects-toProlactin connects-toOxytocin connects-toTestosterone connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toCarbon connects-toPd 1 connects-toGlp 1 connects-toRankl connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toMyostatin connects-toCortisol connects-toGhrelin