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testosterone
Testosterone
19-carbon androgen from Leydig cells via CYP17A1; binds androgen receptor → spermatogenesis, muscle anabolism, bone density, and libido; 5α-reductase converts to DHT; aromatase to estradiol; hypogonadism causes osteoporosis; prostate cancer driven by testosterone-AR signaling.
Entry Metadata
| Field | Value |
|---|---|
| ID | testosterone |
| Name | Testosterone |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010;95(6):2536-2559. · PubMed 20525905
- Sattler FR, Castaneda-Sceppa C, Binder EF, et al. Testosterone and growth hormone improve body composition and muscle performance in older men. J Clin Endocrinol Metab. 2009;94(6):1991-2001. · PubMed 19293261
- Shores MM, Kivlahan DR, Sadak TI, Li EJ, Matsumoto AM. A randomized, double-blind, placebo-controlled study of testosterone treatment in hypogonadal older men with subthreshold depression (dysthymia or minor depression). J Clin Psychiatry. 2009;70(7):1009-1016. · PubMed 19538904