Atlas One · Host Biology · Scale 07 — System

Prostate Cancer

Second leading cancer death in men; driven by androgen receptor (AR) signaling; PTEN loss (~50%) and AR amplification underlie castration-resistant progression. Docetaxel, abiraterone, enzalutamide, olaparib (BRCA-mutant HRR deficient), and lutetium-177-PSMA are active in mCRPC.

Also known as: PCa, prostate adenocarcinoma, CRPC, castration-resistant prostate cancer, mCRPC, hormone-sensitive prostate cancer, mCSPC, CSPC

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
prostate-cancer

Prostate Cancer

Second leading cancer death in men; driven by androgen receptor (AR) signaling; PTEN loss (~50%) and AR amplification underlie castration-resistant progression. Docetaxel, abiraterone, enzalutamide, olaparib (BRCA-mutant HRR deficient), and lutetium-177-PSMA are active in mCRPC.

Entry Metadata

FieldValue
IDprostate-cancer
NameProstate Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toAndrogen Receptor connects-toPten connects-toBrca1 connects-toMtor connects-toTestosterone connects-toReproductive System connects-toBrca2 connects-toRankl connects-toColorectal Cancer connects-toOsteoblast connects-toBreast Cancer connects-toPhoton connects-toLynch Syndrome connects-toDendritic Cell connects-toHereditary Breast Ovarian Cancer connects-toPancreatic Cancer connects-toBladder Cancer connects-toMyc connects-toOsteoclast connects-toBone Marrow connects-toLiver connects-toLung connects-toT Cytotoxic Cell connects-toAtm connects-toNeuroendocrine Tumors connects-toCalcium connects-toAkt connects-toRegulatory T Cell connects-toMacrophage connects-toZinc connects-toKidney connects-toFibroblast connects-toPhosphorus connects-toNeuron connects-toAdrenal Gland connects-toElectron connects-toHeart connects-toBrain connects-toErythrocyte connects-toAdipocyte connects-toLarge Intestine connects-toAntibody connects-toLymphatic System connects-toNeutrophil connects-toP53 connects-toOsteoporosis connects-toSelenium connects-toPd 1 connects-toObesity connects-toVegf connects-toNf Kb connects-toVenous Thromboembolism connects-toSepsis connects-toAnemia Of Chronic Disease connects-toCkd connects-toType 2 Diabetes connects-toHeart Failure connects-toNeuropathic Pain connects-toMajor Depressive Disorder connects-toEndocrine System connects-toRenal System connects-toGeneralized Anxiety Disorder connects-toMusculoskeletal System connects-toNervous System connects-toCardiovascular System connects-toImmune System connects-toDigestive System connects-toRespiratory System connects-toTargeted Therapy connects-toIntegumentary System connects-toSulforaphane connects-toCancer Chemotherapy connects-toCortical Bone connects-toCheckpoint Inhibitors connects-toOvarian Cancer connects-toSclc connects-toArterial Wall connects-toHepatic Lobule connects-toMelanoma connects-toDisseminated Intravascular Coagulation connects-toRetinoblastoma connects-toAtherosclerosis connects-toPeripheral Nerve connects-toEzh2 connects-toCyclin D1 connects-toHif 1Alpha connects-toEndothelin 1 connects-toTert connects-toCcl2 connects-toCxcl12 connects-toRad51 connects-toIgf 1 connects-toGlucocorticoid Receptor connects-toSstr2 connects-toCgas Sting connects-toPik3Ca connects-toWnt Beta Catenin connects-toTgf Beta connects-toErk1 2 connects-toE2F1 connects-toMdm2 connects-toIl 6 connects-toSmad4 connects-toCdkn2A connects-toGalectin 3 connects-toStat3 connects-toStat1 connects-toFoxo connects-toCdk4 6 connects-toPerforin connects-toGsk 3B connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toDll3 connects-toAxl Receptor connects-toMhc Class Ii connects-toIl 2 connects-toHemoglobin connects-toTroponin Complex connects-toProton connects-toIl 10 connects-toXanthine Oxidase connects-toIl 4 connects-toIron connects-toProstaglandins connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toMacrophage connects-toFibroblast connects-toIfn Gamma connects-toIl 12 connects-toNatural Killer Cell connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toB Cell connects-toT Helper Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toPeriostin connects-toC1 Esterase Inhibitor connects-toSerotonin connects-toMelatonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toChloride connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toFibronectin connects-toNotch connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin

Sources