Atlas One · Host Biology · Scale 03 — Molecular

ATM

ATM kinase senses DNA double-strand breaks → phosphorylates H2AX, CHK2, BRCA1, and p53 → cell cycle arrest and HR repair. Germline ATM mutations cause ataxia-telangiectasia; somatic ATM deletion in ~15% of CLL and ~40% of mantle cell lymphoma.

Also known as: ATM, Ataxia-Telangiectasia Mutated, AT1, ATM kinase, DNA damage response, double-strand break repair, ataxia-telangiectasia

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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atm

ATM

ATM kinase senses DNA double-strand breaks → phosphorylates H2AX, CHK2, BRCA1, and p53 → cell cycle arrest and HR repair. Germline ATM mutations cause ataxia-telangiectasia; somatic ATM deletion in ~15% of CLL and ~40% of mantle cell lymphoma.

Entry Metadata

FieldValue
IDatm
NameATM
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toP53 connects-toBrca1 connects-toNf Kb connects-toBcl 2 connects-toRad51 connects-toCll connects-toMantle Cell Lymphoma

Sources