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p53
p53
Transcription factor and master tumor suppressor encoded by TP53; activated by DNA damage, oncogene activation, and hypoxia. Triggers cell-cycle arrest (p21/CDKN1A), apoptosis (PUMA, BAX), and senescence. Mutated in >50% of human cancers; 'guardian of the genome.'
Entry Metadata
| Field | Value |
|---|---|
| ID | p53 |
| Name | p53 |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Lane DP. Cancer. p53, guardian of the genome. Nature. 1992;358(6381):15-16. · PubMed 1614522
- Vousden KH, Prives C. Blinded by the Light: The Growing Complexity of p53. Cell. 2009;137(3):413-431. · PubMed 19410540
- Levine AJ. p53: 800 million years of evolution and 40 years of discovery. Nat Rev Cancer. 2020;20(8):471-480. · PubMed 32404993