Atlas One · Host Biology · Scale 07 — System

Cytokine Storm

Dysregulated systemic immune amplification with massive cytokine release (IL-6, TNF-α, IL-1β, IFN-γ). Macrophage-T cell loop causes ARDS, DIC, organ failure. Triggers: COVID-19, CAR-T CRS, HLH. Treatment: tocilizumab, dexamethasone, anakinra.

Also known as: cytokine storm, cytokine release syndrome, CRS, hypercytokinemia, macrophage activation syndrome, MAS, HLH

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
cytokine-storm

Cytokine Storm

Dysregulated systemic immune amplification with massive cytokine release (IL-6, TNF-α, IL-1β, IFN-γ). Macrophage-T cell loop causes ARDS, DIC, organ failure. Triggers: COVID-19, CAR-T CRS, HLH. Treatment: tocilizumab, dexamethasone, anakinra.

Entry Metadata

FieldValue
IDcytokine-storm
NameCytokine Storm
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

modulated-byMacrophage modulated-byIl 6 modulated-byTnf Alpha modulated-byNf Kb modulatesLung modulated-byDexamethasone

Sources