Atlas One · Host Biology · Scale 07 — System

Diffuse Large B-Cell Lymphoma

Most common aggressive B-cell lymphoma (30% of NHL); GCB subtype driven by t(14;18)/BCL-2 and BCR-PI3K; ABC subtype by MYD88/CD79B/NF-κB. R-CHOP is frontline; CAR-T (axi-cel, liso-cel) and bispecifics (epcoritamab, glofitamab) are approved in relapsed/refractory DLBCL.

Also known as: DLBCL, diffuse large B-cell lymphoma, DLBCL NOS, large B-cell lymphoma, aggressive NHL, LBCL

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
dlbcl

Diffuse Large B-Cell Lymphoma

Most common aggressive B-cell lymphoma (30% of NHL); GCB subtype driven by t(14;18)/BCL-2 and BCR-PI3K; ABC subtype by MYD88/CD79B/NF-κB. R-CHOP is frontline; CAR-T (axi-cel, liso-cel) and bispecifics (epcoritamab, glofitamab) are approved in relapsed/refractory DLBCL.

Entry Metadata

FieldValue
IDdlbcl
NameDiffuse Large B-Cell Lymphoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toNf Kb connects-toBcl 2 connects-toMyc connects-toPd 1 connects-toEzh2 connects-toFollicular Lymphoma connects-toCd20 connects-toB Cell connects-toEpstein Barr Virus connects-toBurkitt Lymphoma connects-toCll connects-toPcnsl connects-toGerminal Center connects-toMantle Cell Lymphoma connects-toHodgkin Lymphoma connects-toMultiple Myeloma connects-toPlasma Cell connects-toHiv Aids connects-toP53 connects-toLymphatic System connects-toBone Marrow connects-toPhoton connects-toT Cytotoxic Cell connects-toStomach connects-toMacrophage connects-toBtk connects-toSpleen connects-toNatural Killer Cell connects-toPotassium connects-toBrain connects-toDendritic Cell connects-toIron connects-toLiver connects-toRegulatory T Cell connects-toPhosphorus connects-toSkin connects-toPeripheral Nerve connects-toElectron connects-toKidney connects-toCalcium connects-toAntibody connects-toNeuron connects-toHeart connects-toCardiomyocyte connects-toHepatitis B connects-toStat3 connects-toBaff connects-toCytokine Storm connects-toT Helper Cell connects-toMyd88 connects-toSjogrens Syndrome connects-toEndothelial Cell connects-toVenous Thromboembolism connects-toSepsis connects-toNervous System connects-toHepatitis B Virus connects-toPneumocystis Jirovecii connects-toHeart Failure connects-toNeuropathic Pain connects-toCkd connects-toMajor Depressive Disorder connects-toDigestive System connects-toVaricella Zoster Virus connects-toGeneralized Anxiety Disorder connects-toCardiovascular System connects-toRespiratory System connects-toEndocrine System connects-toRenal System connects-toMusculoskeletal System connects-toReproductive System connects-toCancer Chemotherapy connects-toCar T connects-toHiv 1 connects-toTargeted Therapy connects-toCheckpoint Inhibitors connects-toMyocardium connects-toWaldenstrom Macroglobulinemia connects-toIntestinal Epithelium connects-toRheumatoid Arthritis connects-toHepatitis C connects-toThyroid connects-toGlomerulus connects-toHelicobacter Pylori connects-toHepatitis C Virus connects-toFoxo1 connects-toAkt connects-toCdk4 6 connects-toHif 1Alpha connects-toPik3Ca connects-toTert connects-toCcl2 connects-toJak1 2 connects-toCxcl12 connects-toMdm2 connects-toPerforin connects-toComplement C3 connects-toCaspase 3 connects-toPten connects-toE2F1 connects-toCdkn2A connects-toErk1 2 connects-toRb1 connects-toIl 6 connects-toMtor connects-toGalectin 3 connects-toTgf Beta connects-toStat1 connects-toCgas Sting connects-toSmad4 connects-toGsk 3B connects-toS100A8 A9 connects-toNotch connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toCalcineurin connects-toAdenosine connects-toOsteopontin connects-toMhc Class Ii connects-toIl 2 connects-toXanthine Oxidase connects-toTroponin Complex connects-toHemoglobin connects-toProton connects-toIl 10 connects-toVegf connects-toIl 4 connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toHepcidin connects-toBurkitt Lymphoma connects-toCll connects-toPotassium connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toPeriostin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toProlactin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toChloride connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toOxygen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine

Sources