Atlas One · Host Biology · Scale 07 — System

Hodgkin Lymphoma

Hodgkin lymphoma is a GC B cell-derived malignancy; RS cells ~100% CD30+; 9p24.1 amplification drives CD30+PD-L1/L2 co-expression; A+AVD (ECHELON-1) is standard for advanced stage; nivolumab/pembrolizumab for R/R; 5-year OS >85% overall; NLPHL has distinct CD20+ biology.

Also known as: Hodgkin lymphoma, HL, cHL, classical Hodgkin lymphoma, NLPHL, Reed-Sternberg, Hodgkin disease, nodular sclerosis HL, mixed cellularity HL

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hodgkin-lymphoma

Hodgkin Lymphoma

Hodgkin lymphoma is a GC B cell-derived malignancy; RS cells ~100% CD30+; 9p24.1 amplification drives CD30+PD-L1/L2 co-expression; A+AVD (ECHELON-1) is standard for advanced stage; nivolumab/pembrolizumab for R/R; 5-year OS >85% overall; NLPHL has distinct CD20+ biology.

Entry Metadata

FieldValue
IDhodgkin-lymphoma
NameHodgkin Lymphoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCd30 connects-toPd 1 connects-toNf Kb connects-toJak2 connects-toGerminal Center connects-toEpstein Barr Virus connects-toCd20 connects-toT Helper Cell connects-toSpleen connects-toLymphatic System connects-toDlbcl connects-toB Cell connects-toHiv Aids connects-toPhoton connects-toMacrophage connects-toCll connects-toNatural Killer Cell connects-toBone Marrow connects-toIl 10 connects-toThymus connects-toErythrocyte connects-toImmune System connects-toAlcohol Use Disorder connects-toHeart connects-toBreast Cancer connects-toRegulatory T Cell connects-toFibrosis connects-toIl 13 connects-toLung connects-toTgf Beta connects-toDendritic Cell connects-toIron connects-toSkin connects-toMast Cell connects-toCalcium connects-toKidney connects-toIl 5 connects-toElectron connects-toLiver connects-toLarge Intestine connects-toAntibody connects-toNeuron connects-toReproductive System connects-toThyroid connects-toMds connects-toPlatelet connects-toStat3 connects-toNeutrophil connects-toHeart Failure connects-toIl 6 connects-toSepsis connects-toVenous Thromboembolism connects-toAnemia Of Chronic Disease connects-toNsclc connects-toPneumocystis Jirovecii connects-toAml connects-toSclc connects-toStroke connects-toNeuropathic Pain connects-toAspergillus Fumigatus connects-toMajor Depressive Disorder connects-toRespiratory System connects-toEndocrine System connects-toGeneralized Anxiety Disorder connects-toCardiovascular System connects-toIntegumentary System connects-toRenal System connects-toMusculoskeletal System connects-toNervous System connects-toDigestive System connects-toCancer Chemotherapy connects-toTargeted Therapy connects-toCheckpoint Inhibitors connects-toMyocardium connects-toFollicular Lymphoma connects-toCar T connects-toBurkitt Lymphoma connects-toAlveolus connects-toThyroid Cancer connects-toAtherosclerosis connects-toGlomerulus connects-toLeishmania Donovani connects-toHiv 1 connects-toPlasma Cell connects-toGastric Cancer connects-toTnf Alpha connects-toCcl2 connects-toVegf connects-toHif 1Alpha connects-toIfn Gamma connects-toBaff connects-toLmp1 connects-toJak1 2 connects-toPerforin connects-toCaspase 3 connects-toMhc Class Ii connects-toCollagen connects-toIl 4 connects-toNotch connects-toBcl 2 connects-toMyc connects-toMtor connects-toMdm2 connects-toAkt connects-toGalectin 3 connects-toSmad4 connects-toStat1 connects-toCgas Sting connects-toEzh2 connects-toFoxo connects-toS100A8 A9 connects-toErk1 2 connects-toGsk 3B connects-toPik3Ca connects-toSrc Kinase connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toArid1A connects-toCalcineurin connects-toAdenosine connects-toOsteopontin connects-toPhoton connects-toTroponin Complex connects-toIl 2 connects-toHemoglobin connects-toT Cytotoxic Cell connects-toXanthine Oxidase connects-toProstaglandins connects-toNitric Oxide connects-toIge connects-toHepcidin connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toZinc connects-toMantle Cell Lymphoma connects-toIl 12 connects-toSelenium connects-toIl 23 connects-toIl 1B connects-toIl 33 connects-toComplement C5 connects-toC5Ar1 connects-toVitamin D connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toComplement C3 connects-toTslp connects-toHistamine connects-toBradykinin connects-toErythropoietin connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toPhosphorus connects-toChloride connects-toNitrogen connects-toOxygen connects-toCarbon connects-toHydrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine

Sources