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antibody
Antibody
Y-shaped glycoproteins secreted by plasma cells; two heavy + two light chains. Variable domains (VH/VL) confer antigen specificity; constant domains determine isotype (IgG, IgA, IgM, IgE, IgD) and effector functions (neutralization, opsonization, complement activation, ADCC).
Entry Metadata
| Field | Value |
|---|---|
| ID | antibody |
| Name | Antibody |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Schroeder HW Jr, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S41-52. · PubMed 20176268
- Burton DR. Antibodies, viruses and vaccines. Nat Rev Immunol. 2002;2(9):706-713. · PubMed 12209139
- Vidarsson G, Dekkers G, Rispens T. IgG subclasses and allotypes: from structure to effector functions. Front Immunol. 2014;5:520. · PubMed 25368619