Atlas One · Host Biology · Scale 04 — Cellular

Macrophage

Professional phagocyte and innate immune effector. Derived from monocytes; tissue-resident forms include Kupffer cells (liver), microglia (brain), alveolar macrophages (lung). Phagocytoses pathogens and apoptotic cells; secretes IL-6, TNF-α, and ROS upon TLR/NLR activation.

Also known as: tissue macrophage, Kupffer cell, microglia, alveolar macrophage, M1 macrophage, M2 macrophage

Scale 04 — CellularScale
draftStatus
2026-06-05Last Reviewed
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macrophage

Macrophage

Professional phagocyte and innate immune effector. Derived from monocytes; tissue-resident forms include Kupffer cells (liver), microglia (brain), alveolar macrophages (lung). Phagocytoses pathogens and apoptotic cells; secretes IL-6, TNF-α, and ROS upon TLR/NLR activation.

Entry Metadata

FieldValue
IDmacrophage
NameMacrophage
Statusdraft
Last reviewed2026-06-05
Atlas01-human
Scale04-cellular

Cross-Atlas Connections

part-ofImmune System expressesIl 6 expressesTnf Alpha expressesMhc Class Ii damagesHepatocyte part-ofHepatic Lobule part-ofLiver part-ofHuman Body modulated-byNatural Killer Cell modulated-byIntestinal Epithelium part-ofBone Marrow modulated-byStat3 modulated-byNf Kb part-ofSpleen modulated-byComplement C3 modulated-byNitric Oxide modulated-byHistamine expressed-byProstaglandins modulated-byArterial Wall modulated-byNeutrophil modulated-byOsteoclast modulated-byEndothelial Cell modulated-byPlatelet infected-byEbola Virus damaged-byRotavirus modulated-byAkkermansia Muciniphila damaged-byCryptococcus Neoformans damaged-byTrypanosoma Brucei damaged-byTrypanosoma Cruzi damaged-byToxoplasma Gondii infected-byLeishmania Donovani damaged-bySalmonella Typhi damaged-byListeria Monocytogenes damaged-byHelicobacter Pylori modulated-byResveratrol modulated-byQuercetin connects-toFamilial Hypercholesterolemia

Sources