Atlas One · Host Biology · Scale 03 — Molecular

Nitric Oxide

Free radical gas (MW 30.01, t½ <1 s in vivo); synthesised from L-arginine by NOS isoforms (eNOS, nNOS, iNOS). eNOS → vasodilation via sGC/cGMP/PKG; nNOS → synaptic plasticity; iNOS → antimicrobial. Dysregulation: hypertension, septic shock, erectile dysfunction.

Also known as: NO, nitrogen monoxide, endothelium-derived relaxing factor, EDRF, nitric oxide radical, NO•

Scale 03 — MolecularScale
draftStatus
2026-06-05Last Reviewed
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nitric-oxide

Nitric Oxide

Free radical gas (MW 30.01, t½ <1 s in vivo); synthesised from L-arginine by NOS isoforms (eNOS, nNOS, iNOS). eNOS → vasodilation via sGC/cGMP/PKG; nNOS → synaptic plasticity; iNOS → antimicrobial. Dysregulation: hypertension, septic shock, erectile dysfunction.

Entry Metadata

FieldValue
IDnitric-oxide
NameNitric Oxide
Statusdraft
Last reviewed2026-06-05
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

modulatesCardiovascular System modulatesMacrophage modulatesNervous System modulatesNf Kb modulated-byArterial Wall modulated-bySmooth Muscle Cell connects-toPulmonary Arterial Hypertension connects-toMigraine

Sources