Atlas One · Host Biology · Scale 07 — System

Migraine

Migraine (1.1B affected; #2 cause of disability) is a neurovascular disorder with unilateral throbbing headache, nausea, and photophobia; CGRP-mediated trigeminovascular activation drives pain; triptans (5-HT1B/D agonists) and anti-CGRP mAbs are first-line treatments.

Also known as: migraine, migraine with aura, migraine without aura, hemiplegic migraine, chronic migraine, episodic migraine, trigeminovascular, cortical spreading depression, CGRP migraine, triptan, sumatriptan

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
migraine

Migraine

Migraine (1.1B affected; #2 cause of disability) is a neurovascular disorder with unilateral throbbing headache, nausea, and photophobia; CGRP-mediated trigeminovascular activation drives pain; triptans (5-HT1B/D agonists) and anti-CGRP mAbs are first-line treatments.

Entry Metadata

FieldValue
IDmigraine
NameMigraine
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCgrp connects-toSerotonin targetsBrain connects-toStroke connects-toNitric Oxide connects-toScn1A connects-toEpilepsy connects-toEstrogen connects-toAstrocyte connects-toFibromyalgia connects-toInsomnia Disorder connects-toNeuron connects-toNeuropathic Pain connects-toGeneralized Anxiety Disorder connects-toMicroglia connects-toMajor Depressive Disorder connects-toMagnesium connects-toGlutamate connects-toDopamine connects-toCalcium connects-toNervous System connects-toEye connects-toDigestive System connects-toGaba connects-toHeart connects-toPotassium connects-toHistamine connects-toAdenosine connects-toMast Cell connects-toEndothelial Cell connects-toPhoton connects-toStomach connects-toSynapse connects-toSodium connects-toPeripheral Nerve connects-toLarge Intestine connects-toElectron connects-toVitamin D connects-toSkin connects-toAntibody connects-toMelatonin connects-toReproductive System connects-toCardiovascular System connects-toPlatelet connects-toEpinephrine connects-toSubstance P connects-toSmooth Muscle Cell connects-toBipolar Disorder connects-toCalcitonin connects-toObesity connects-toPtsd connects-toNf Kb connects-toPanic Disorder connects-toAsthma connects-toCkd connects-toSocial Anxiety Disorder connects-toObsessive Compulsive Disorder connects-toAtherosclerosis connects-toHypertension connects-toVenous Thromboembolism connects-toEndocrine System connects-toGut Microbiome connects-toMusculoskeletal System connects-toIntegumentary System connects-toRenal System connects-toImmune System connects-toBeta Blockers connects-toMagnesium Dietary connects-toLymphatic System connects-toAspirin connects-toArbs connects-toMultiple Sclerosis connects-toTargeted Therapy connects-toArterial Wall connects-toMyocardium connects-toOrexin connects-toHippocampus connects-toThyroid connects-toAntiphospholipid Syndrome connects-toNarcolepsy connects-toCovid 19 Disease connects-toOpioid Use Disorder connects-toAnorexia Nervosa connects-toEndocardium connects-toIl 6 connects-toTnf Alpha connects-toNorepinephrine connects-toProstaglandins connects-toEndothelin 1 connects-toSerotonin Transporter connects-toProgesterone connects-toBradykinin connects-toAtp connects-toCalcium connects-toKit connects-toOxytocin connects-toConnexin43 connects-toNlrp3 Inflammasome connects-toCrh connects-toTlr4 connects-toNtrk connects-toNfe2L2 connects-toErk1 2 connects-toAkt connects-toGalectin 3 connects-toStat3 connects-toGsk 3B connects-toCgas Sting connects-toFoxo connects-toStat1 connects-toJak1 2 connects-toHif 1Alpha connects-toS100A8 A9 connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toDnmt3A connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toBeta1 Adrenergic Receptor connects-toAngiotensin Ii connects-toTestosterone connects-toMu Opioid Receptor connects-toAldosterone connects-toInsulin connects-toXanthine Oxidase connects-toCholesterol connects-toLeptin connects-toIl 4 connects-toZinc connects-toOmega 3 Fatty Acids connects-toIl 13 connects-toAdiponectin connects-toResistin connects-toAstrocyte connects-toMajor Depressive Disorder connects-toEpilepsy connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toComplement C3 connects-toC5Ar1 connects-toT Cytotoxic Cell connects-toComplement C5 connects-toFactor H connects-toDendritic Cell connects-toTslp connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toPeriostin connects-toProlactin connects-toTransferrin connects-toVasopressin connects-toSelenium connects-toIodine connects-toCopper connects-toPhosphorus connects-toIron connects-toNitrogen connects-toChloride connects-toSulfur connects-toOxygen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toVegf connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toInsulin Receptor connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toRenin connects-toMyostatin connects-toAngiopoietin