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migraine
Migraine
Migraine (1.1B affected; #2 cause of disability) is a neurovascular disorder with unilateral throbbing headache, nausea, and photophobia; CGRP-mediated trigeminovascular activation drives pain; triptans (5-HT1B/D agonists) and anti-CGRP mAbs are first-line treatments.
Entry Metadata
| Field | Value |
|---|---|
| ID | migraine |
| Name | Migraine |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- GBD 2016 Headache Collaborators. Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2018;17(11):954-976. · PubMed 30353868
- Goadsby PJ, Lipton RB, Ferrari MD. Migraine — current understanding and treatment. N Engl J Med. 2002;346(4):257-270. · PubMed 11807151
- Dodick DW, Ashina M, Brandes JL, et al. ARISE: A Phase 3 randomized trial of erenumab for episodic migraine. Cephalalgia. 2018;38(6):1026-1037. · PubMed 29471679