Atlas One · Host Biology · Scale 07 — System

Obsessive-Compulsive Disorder

OCD (2-3% lifetime prevalence) is driven by cortico-striato-thalamo-cortical circuit hyperactivity; SSRIs at high doses are first-line; CBT with ERP achieves remission in ~60%; glutamatergic and dopaminergic dysregulation underlie treatment-resistant OCD.

Also known as: OCD, obsessive compulsive disorder, obsessive-compulsive, OCD spectrum, CSTC circuit, contamination OCD, checking OCD, hoarding disorder

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
obsessive-compulsive-disorder

Obsessive-Compulsive Disorder

OCD (2-3% lifetime prevalence) is driven by cortico-striato-thalamo-cortical circuit hyperactivity; SSRIs at high doses are first-line; CBT with ERP achieves remission in ~60%; glutamatergic and dopaminergic dysregulation underlie treatment-resistant OCD.

Entry Metadata

FieldValue
IDobsessive-compulsive-disorder
NameObsessive-Compulsive Disorder
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSerotonin connects-toDopamine connects-toGlutamate connects-toGaba connects-toBrain connects-toMajor Depressive Disorder connects-toGeneralized Anxiety Disorder connects-toStreptococcus Pyogenes connects-toBorderline Personality Disorder connects-toAutism Spectrum Disorder connects-toAnorexia Nervosa connects-toPanic Disorder connects-toSchizophrenia connects-toNeuron connects-toPtsd connects-toBipolar Disorder connects-toInternet Gaming Disorder connects-toCortisol connects-toSocial Anxiety Disorder connects-toHippocampus connects-toBdnf connects-toAttention Deficit Hyperactivity Disorder connects-toHuntingtons Disease connects-toMicroglia connects-toMhc Class Ii connects-toInsomnia Disorder connects-toComplement C3 connects-toAstrocyte connects-toOxytocin connects-toSynapse connects-toCalcium connects-toB Cell connects-toPhoton connects-toOligodendrocyte connects-toLarge Intestine connects-toSkin connects-toZinc connects-toHeart connects-toNorepinephrine connects-toMelatonin connects-toMagnesium connects-toAntibody connects-toReproductive System connects-toGut Microbiome connects-toT Helper Cell connects-toBulimia Nervosa connects-toIl 6 connects-toNervous System connects-toRegulatory T Cell connects-toEndocannabinoid connects-toNf Kb connects-toParkinsons Disease connects-toAlcohol Use Disorder connects-toBinge Eating Disorder connects-toCannabis Use Disorder connects-toEpilepsy connects-toMigraine connects-toAtopic Dermatitis connects-toObesity connects-toIntegumentary System connects-toCardiovascular System connects-toDigestive System connects-toImmune System connects-toRenal System connects-toEndocrine System connects-toMusculoskeletal System connects-toRespiratory System connects-toFluoxetine connects-toLymphatic System connects-toOmega 3 Fatty Acids connects-toAshwagandha connects-toGambling Disorder connects-toSt Johns Wort connects-toPanax Ginseng connects-toCardiac Conduction System connects-toType 2 Diabetes connects-toStimulant Use Disorder connects-toStroke connects-toOpioid Use Disorder connects-toFibromyalgia connects-toCovid 19 Disease connects-toIntestinal Epithelium connects-toMultiple Sclerosis connects-toIl 1B connects-toTnf Alpha connects-toNlrp3 Inflammasome connects-toSerotonin Transporter connects-toCrh connects-toIl 17A connects-toEstrogen connects-toTlr4 connects-toMu Opioid Receptor connects-toAcetylcholine connects-toSubstance P connects-toNitric Oxide connects-toGlucocorticoid Receptor connects-toMtor connects-toErk1 2 connects-toGsk 3B connects-toAkt connects-toActh connects-toMyd88 connects-toPten connects-toAdenosine connects-toNtrk connects-toStat3 connects-toGalectin 3 connects-toCgas Sting connects-toJak1 2 connects-toFoxo connects-toHif 1Alpha connects-toS100A8 A9 connects-toStat1 connects-toPik3Ca connects-toAmpk connects-toDnmt3A connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toArid1A connects-toImmunoglobulin G connects-toHistamine connects-toProgesterone connects-toIl 2 connects-toAngiotensin Ii connects-toTestosterone connects-toIl 10 connects-toProstaglandins connects-toXanthine Oxidase connects-toIl 4 connects-toCopper connects-toVitamin D connects-toIl 13 connects-toGeneralized Anxiety Disorder connects-toZinc connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Cytotoxic Cell connects-toNatural Killer Cell connects-toComplement C5 connects-toC5Ar1 connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toErythropoietin connects-toProlactin connects-toVasopressin connects-toTransferrin connects-toFactor H connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toPhosphorus connects-toIron connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toVegf connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr