Atlas One · Host Biology · Scale 03 — Molecular

CRH

Hypothalamic neuropeptide (CRH gene, chr8q13) initiating the HPA axis: PVN → CRHR1 → ACTH → cortisol. Extra-hypothalamic CRH in amygdala/BNST drives stress arousal via LC-NE activation; CRHR1 antagonists investigated for AUD, PTSD, and MDD.

Also known as: CRH, CRF, corticotropin-releasing hormone, corticotropin-releasing factor, CRHR1, CRHR2, PVN, HPA axis

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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crh

CRH

Hypothalamic neuropeptide (CRH gene, chr8q13) initiating the HPA axis: PVN → CRHR1 → ACTH → cortisol. Extra-hypothalamic CRH in amygdala/BNST drives stress arousal via LC-NE activation; CRHR1 antagonists investigated for AUD, PTSD, and MDD.

Entry Metadata

FieldValue
IDcrh
NameCRH
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

modulatesCortisol modulatesNorepinephrine connects-toGaba modulatesBrain connects-toAlcohol Use Disorder connects-toPtsd connects-toMajor Depressive Disorder modulatesActh

Sources