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alcohol-use-disorder
Alcohol Use Disorder
Alcohol use disorder (14.5% lifetime) involves GABA-A potentiation → tolerance and withdrawal seizures (glutamate rebound), VTA-dopamine reward, and CRF-driven negative reinforcement; treatment: naltrexone, acamprosate, benzodiazepine detox, CBT, 12-step programs.
Entry Metadata
| Field | Value |
|---|---|
| ID | alcohol-use-disorder |
| Name | Alcohol Use Disorder |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toGaba
connects-toGlutamate
connects-toDopamine
connects-toSerotonin
connects-toBdnf
targetsBrain
connects-toCrh
connects-toMu Opioid Receptor
connects-toNorepinephrine
connects-toNpy
connects-toLiver
connects-toHcc
connects-toOpioid Use Disorder
connects-toStimulant Use Disorder
connects-toMajor Depressive Disorder
connects-toHepatocyte
connects-toEsophageal Cancer
connects-toCardiomyocyte
connects-toCortisol
connects-toNeuron
connects-toNash
connects-toGut Microbiome
connects-toPancreas
connects-toPlacenta
connects-toBreast Cancer
connects-toHippocampus
connects-toColorectal Cancer
connects-toErythrocyte
connects-toMagnesium
connects-toSynapse
connects-toStomach
connects-toHydrogen
connects-toHeart
connects-toPlatelet
connects-toPhoton
connects-toPeripheral Nerve
connects-toZinc
connects-toElectron
connects-toSkin
connects-toPhosphorus
connects-toBone Marrow
connects-toReproductive System
connects-toNeutrophil
connects-toMelatonin
connects-toOsteoporosis
connects-toEndothelial Cell
connects-toTestosterone
connects-toMacrophage
connects-toHypertension
connects-toMicroglia
connects-toStroke
connects-toBipolar Disorder
connects-toNf Kb
connects-toNervous System
connects-toSepsis
connects-toPancreatic Cancer
connects-toHeart Failure
connects-toCkd
connects-toNeuropathic Pain
connects-toHnscc
connects-toGeneralized Anxiety Disorder
connects-toDigestive System
connects-toEndocrine System
connects-toImmune System
connects-toCardiovascular System
connects-toMusculoskeletal System
connects-toIntegumentary System
connects-toRespiratory System
connects-toRenal System
connects-toMagnesium Dietary
connects-toMycobacterium Tuberculosis
connects-toPtsd
connects-toOsteoblast
connects-toHepatic Lobule
connects-toMyocardium
connects-toCancer Chemotherapy
connects-toCardiac Conduction System
connects-toEpilepsy
connects-toGout
connects-toHereditary Pancreatitis
connects-toAlzheimers Disease
connects-toIron Deficiency Anemia
connects-toAlveolus
connects-toStreptococcus Pneumoniae
connects-toWound Healing
connects-toTnf Alpha
connects-toIl 6
connects-toNlrp3 Inflammasome
connects-toTlr4
connects-toEndocannabinoid
connects-toAdenosine
connects-toOrexin
connects-toGhrelin
connects-toAcetylcholine
connects-toGlp 1
connects-toTgf Beta
connects-toOxytocin
connects-toErk1 2
connects-toGlucocorticoid Receptor
connects-toNfe2L2
connects-toMyd88
connects-toMtor
connects-toNtrk
connects-toAkt
connects-toGalectin 3
connects-toJak1 2
connects-toGsk 3B
connects-toStat3
connects-toCgas Sting
connects-toFoxo
connects-toStat1
connects-toS100A8 A9
connects-toHif 1Alpha
connects-toPik3Ca
connects-toDnmt3A
connects-toAmpk
connects-toAutophagy
connects-toCcr5
connects-toSrc Kinase
connects-toCxcl12
connects-toIl 1B
connects-toIl 33
connects-toIl 17A
connects-toComplement C3
connects-toEstrogen
connects-toXanthine Oxidase
connects-toTroponin Complex
connects-toHemoglobin
connects-toAldosterone
connects-toInsulin
connects-toCholesterol
connects-toPotassium
connects-toProstaglandins
connects-toIl 4
connects-toHepcidin
connects-toIron
connects-toIl 13
connects-toFibroblast
connects-toLeptin
connects-toAdiponectin
connects-toResistin
connects-toCannabis Use Disorder
connects-toType I Interferon
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toMast Cell
connects-toT Cytotoxic Cell
connects-toAstrocyte
connects-toComplement C5
connects-toC5Ar1
connects-toTransferrin
connects-toTslp
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toHistamine
connects-toErythropoietin
connects-toFactor H
connects-toProlactin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toSodium
connects-toCopper
connects-toCalcium
connects-toNitrogen
connects-toChloride
connects-toOxygen
connects-toCarbon
connects-toSulfur
connects-toPd 1
connects-toAngiotensin Ii
connects-toVegf
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAndrogen Receptor
connects-toAdrenomedullin
connects-toOsteopontin
connects-toFgfr
connects-toEpinephrine
connects-toRenin
Sources
- Rehm J, Shield KD. Global Burden of Alcohol Use Disorders and Alcohol Liver Disease. Biomedicines. 2019;7(4):99. · PubMed 31752397
- Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;35(1):217-238. · PubMed 19710631
- Anton RF, O'Malley SS, Ciraulo DA, et al. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study. JAMA. 2006;295(17):2003-2017. · PubMed 16670409