Atlas One · Host Biology · Scale 07 — System

Alcohol Use Disorder

Alcohol use disorder (14.5% lifetime) involves GABA-A potentiation → tolerance and withdrawal seizures (glutamate rebound), VTA-dopamine reward, and CRF-driven negative reinforcement; treatment: naltrexone, acamprosate, benzodiazepine detox, CBT, 12-step programs.

Also known as: alcohol use disorder, AUD, alcoholism, alcohol dependence, AUDIT, naltrexone, acamprosate, Wernicke-Korsakoff, alcohol withdrawal, CIWA

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
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alcohol-use-disorder

Alcohol Use Disorder

Alcohol use disorder (14.5% lifetime) involves GABA-A potentiation → tolerance and withdrawal seizures (glutamate rebound), VTA-dopamine reward, and CRF-driven negative reinforcement; treatment: naltrexone, acamprosate, benzodiazepine detox, CBT, 12-step programs.

Entry Metadata

FieldValue
IDalcohol-use-disorder
NameAlcohol Use Disorder
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toGaba connects-toGlutamate connects-toDopamine connects-toSerotonin connects-toBdnf targetsBrain connects-toCrh connects-toMu Opioid Receptor connects-toNorepinephrine connects-toNpy

Sources