Atlas One · Host Biology · Scale 03 — Molecular

Endocannabinoid System

Retrograde lipid signaling system: 2-AG and AEA activate CB1R (Gi, presynaptic) to suppress neurotransmitter release on demand. Regulates synaptic plasticity, appetite, pain, anxiety, and stress. THC mimics AEA; rimonabant (CB1R antagonist) caused psychiatric adverse events.

Also known as: endocannabinoid, endocannabinoid system, ECS, CB1R, CB2R, 2-AG, anandamide, AEA, FAAH, MAGL, cannabinoid receptor, THC, retrograde signaling

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
endocannabinoid

Endocannabinoid System

Retrograde lipid signaling system: 2-AG and AEA activate CB1R (Gi, presynaptic) to suppress neurotransmitter release on demand. Regulates synaptic plasticity, appetite, pain, anxiety, and stress. THC mimics AEA; rimonabant (CB1R antagonist) caused psychiatric adverse events.

Entry Metadata

FieldValue
IDendocannabinoid
NameEndocannabinoid System
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

modulatesDopamine modulatesGaba modulatesGlutamate connects-toBdnf modulatesBrain connects-toCannabis Use Disorder connects-toPtsd connects-toBinge Eating Disorder

Sources