Atlas One · Host Biology · Scale 03 — Molecular

BDNF

BDNF activates TrkB → MAPK/PI3K → neuronal survival, dendritic complexity, and LTP; reduced in MDD, Alzheimer's, and with aging; exercise robustly raises BDNF; Val66Met SNP impairs activity-dependent secretion and elevates risk for depression and cognitive decline.

Also known as: brain-derived neurotrophic factor, BDNF, NGF-2, BDNF Val66Met, TrkB ligand, neurotrophin, NTRK2 ligand, BDNF neuroplasticity, hippocampal BDNF

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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bdnf

BDNF

BDNF activates TrkB → MAPK/PI3K → neuronal survival, dendritic complexity, and LTP; reduced in MDD, Alzheimer's, and with aging; exercise robustly raises BDNF; Val66Met SNP impairs activity-dependent secretion and elevates risk for depression and cognitive decline.

Entry Metadata

FieldValue
IDbdnf
NameBDNF
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toMajor Depressive Disorder connects-toAlzheimers Disease connects-toParkinsons Disease modulatesBrain connects-toPtsd connects-toBipolar Disorder connects-toHuntingtons Disease connects-toAttention Deficit Hyperactivity Disorder connects-toAlcohol Use Disorder connects-toOpioid Use Disorder connects-toAnorexia Nervosa connects-toStimulant Use Disorder connects-toEndocannabinoid connects-toCannabis Use Disorder connects-toInternet Gaming Disorder connects-toBinge Eating Disorder connects-toNeuropathic Pain connects-toNarcolepsy modulated-byMicroglia modulated-byFluoxetine

Sources