Atlas One · Host Biology · Scale 07 — System

Alzheimer's Disease

Neurodegenerative disease defined by amyloid-β plaques and tau tangles; progressive memory loss and dementia. APOE4 is the major genetic risk factor. Anti-amyloid antibodies (lecanemab, donanemab) slow early-stage progression; symptomatic treatment with cholinesterase inhibitors.

Also known as: AD, Alzheimer disease, senile dementia, LOAD, late-onset Alzheimer's

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
alzheimers-disease

Alzheimer's Disease

Neurodegenerative disease defined by amyloid-β plaques and tau tangles; progressive memory loss and dementia. APOE4 is the major genetic risk factor. Anti-amyloid antibodies (lecanemab, donanemab) slow early-stage progression; symptomatic treatment with cholinesterase inhibitors.

Entry Metadata

FieldValue
IDalzheimers-disease
NameAlzheimer's Disease
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

targetsBrain connects-toMicroglia connects-toNlrp3 Inflammasome connects-toAutophagy connects-toApoe connects-toApp connects-toMapt connects-toLewy Body Dementia connects-toGsk 3B connects-toSnca connects-toMelatonin connects-toInsulin connects-toTdp 43 connects-toGlp 1 connects-toIgf 1 connects-toParkinsons Disease connects-toNeuron connects-toType 2 Diabetes connects-toAcetylcholine connects-toHippocampus connects-toAstrocyte connects-toComplement C3 connects-toAtherosclerosis connects-toMajor Depressive Disorder connects-toGlutamate connects-toT Cytotoxic Cell connects-toZinc connects-toIron connects-toOligodendrocyte connects-toBdnf connects-toSynapse connects-toCalcium connects-toEye connects-toPhoton connects-toHeart connects-toCopper connects-toElectron connects-toLarge Intestine connects-toMagnesium connects-toAntibody connects-toEndothelial Cell connects-toOrexin connects-toLymphatic System connects-toCholesterol connects-toThyroid connects-toInsomnia Disorder connects-toGut Microbiome connects-toIl 6 connects-toComplement C5 connects-toHypertension connects-toNatural Killer Cell connects-toNf Kb connects-toSepsis connects-toVenous Thromboembolism connects-toEpilepsy connects-toStroke connects-toOsteoporosis connects-toStreptococcus Pneumoniae connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toNervous System connects-toMusculoskeletal System connects-toDigestive System connects-toRespiratory System connects-toImmune System connects-toCardiovascular System connects-toEndocrine System connects-toReproductive System connects-toIntegumentary System connects-toRenal System connects-toHerpesvirus connects-toGinkgo Biloba connects-toTargeted Therapy connects-toAxonal Transport connects-toArterial Wall connects-toAls connects-toHuntingtons Disease connects-toSchizophrenia connects-toObesity connects-toCovid 19 Disease connects-toLiver connects-toPtsd connects-toNarcolepsy connects-toBipolar Disorder connects-toTnf Alpha connects-toIl 1B connects-toHif 1Alpha connects-toCgas Sting connects-toCcl2 connects-toMtor connects-toTlr4 connects-toCaspase 3 connects-toVegf connects-toRage connects-toGalectin 3 connects-toNorepinephrine connects-toAkt connects-toNfe2L2 connects-toCalcineurin connects-toAquaporin 4 connects-toErk1 2 connects-toMyd88 connects-toJak1 2 connects-toStat3 connects-toPten connects-toStat1 connects-toNtrk connects-toSmad4 connects-toFoxo connects-toS100A8 A9 connects-toPerforin connects-toPik3Ca connects-toAmpk connects-toCdk4 6 connects-toDnmt3A connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toArid1A connects-toAdenosine connects-toOsteopontin connects-toImmunoglobulin G connects-toEstrogen connects-toMhc Class Ii connects-toAngiotensin Ii connects-toProgesterone connects-toHistamine connects-toXanthine Oxidase connects-toProstaglandins connects-toSerotonin connects-toIl 4 connects-toIl 10 connects-toOmega 3 Fatty Acids connects-toIl 13 connects-toLeptin connects-toResistin connects-toAdiponectin connects-toCopper connects-toType 2 Diabetes connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toC5Ar1 connects-toTransferrin connects-toFactor H connects-toC1 Esterase Inhibitor connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toPeriostin connects-toProlactin connects-toOxytocin connects-toTestosterone connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toPhosphorus connects-toNitrogen connects-toChloride connects-toSulfur connects-toOxygen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toNotch connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin connects-toGlucagon

Sources