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snca
SNCA
SNCA encodes alpha-synuclein, a presynaptic protein; point mutations (A53T, A30P, E46K) and copy number gains → toxic misfolding and Lewy body formation → dopaminergic neuron degeneration; prion-like propagation via synaptic connections drives Parkinson disease progression.
Entry Metadata
| Field | Value |
|---|---|
| ID | snca |
| Name | SNCA |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 1997;276(5321):2045-2047. · PubMed 9197268
- Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature. 1997;388(6645):839-840. · PubMed 9278044