Atlas One · Host Biology · Scale 07 — System

Parkinson's Disease

Neurodegenerative disease from dopaminergic neuron loss in the substantia nigra; alpha-synuclein Lewy bodies are the pathological hallmark. Cardinal features: bradykinesia, rigidity, resting tremor. Levodopa/carbidopa is mainstay therapy; no disease-modifying therapy approved.

Also known as: PD, Parkinson disease, paralysis agitans, idiopathic Parkinson's

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
parkinsons-disease

Parkinson's Disease

Neurodegenerative disease from dopaminergic neuron loss in the substantia nigra; alpha-synuclein Lewy bodies are the pathological hallmark. Cardinal features: bradykinesia, rigidity, resting tremor. Levodopa/carbidopa is mainstay therapy; no disease-modifying therapy approved.

Entry Metadata

FieldValue
IDparkinsons-disease
NameParkinson's Disease
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

targetsBrain connects-toMicroglia connects-toAutophagy connects-toAlzheimers Disease connects-toSnca connects-toLrrk2 connects-toMapt connects-toLewy Body Dementia connects-toDopamine connects-toNeuron connects-toNeuropathic Pain connects-toMajor Depressive Disorder connects-toGut Microbiome connects-toHuntingtons Disease connects-toSchizophrenia connects-toNarcolepsy connects-toAstrocyte connects-toNorepinephrine connects-toSerotonin connects-toNervous System connects-toAcetylcholine connects-toIron connects-toDigestive System connects-toGlutamate connects-toT Helper Cell connects-toHeart connects-toCalcium connects-toAtp connects-toRegulatory T Cell connects-toSynapse connects-toLarge Intestine connects-toTnf Alpha connects-toPhoton connects-toSkin connects-toOligodendrocyte connects-toElectron connects-toEye connects-toCopper connects-toStomach connects-toMelatonin connects-toSmooth Muscle Cell connects-toAntibody connects-toGaba connects-toReproductive System connects-toMelanoma connects-toPeripheral Nerve connects-toT Cytotoxic Cell connects-toNlrp3 Inflammasome connects-toType 2 Diabetes connects-toNatural Killer Cell connects-toNf Kb connects-toInsomnia Disorder connects-toSepsis connects-toOsteoporosis connects-toGeneralized Anxiety Disorder connects-toCkd connects-toStreptococcus Pneumoniae connects-toVenous Thromboembolism connects-toStroke connects-toGambling Disorder connects-toMusculoskeletal System connects-toRenal System connects-toCardiovascular System connects-toIntegumentary System connects-toRespiratory System connects-toImmune System connects-toLymphatic System connects-toEndocrine System connects-toHelicobacter Pylori connects-toInfluenza A connects-toGinkgo Biloba connects-toAxonal Transport connects-toMyocardium connects-toPanax Ginseng connects-toIntestinal Epithelium connects-toHippocampus connects-toCovid 19 Disease connects-toArterial Wall connects-toAls connects-toBipolar Disorder connects-toAlveolus connects-toEndocardium connects-toFibromyalgia connects-toIl 1B connects-toIl 6 connects-toMtor connects-toCcl2 connects-toIfn Gamma connects-toGlp 1 connects-toTlr4 connects-toFerroportin connects-toCgas Sting connects-toCalcium connects-toXanthine Oxidase connects-toBdnf connects-toNfe2L2 connects-toCaspase 3 connects-toComplement C3 connects-toAmpk connects-toGsk 3B connects-toMyd88 connects-toAkt connects-toJak1 2 connects-toGalectin 3 connects-toStat1 connects-toStat3 connects-toPten connects-toFoxo connects-toS100A8 A9 connects-toErk1 2 connects-toHif 1Alpha connects-toPik3Ca connects-toPerforin connects-toDnmt3A connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 17A connects-toIl 33 connects-toArid1A connects-toCalcineurin connects-toAdenosine connects-toEstrogen connects-toAngiotensin Ii connects-toInsulin connects-toIl 2 connects-toProgesterone connects-toIl 4 connects-toIl 10 connects-toSmall Intestine connects-toProstaglandins connects-toNitric Oxide connects-toZinc connects-toMagnesium connects-toIl 13 connects-toHepcidin connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toB Cell connects-toMast Cell connects-toIge connects-toTransferrin connects-toDendritic Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toMacrophage connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toPeriostin connects-toC1 Esterase Inhibitor connects-toTestosterone connects-toOxytocin connects-toVasopressin connects-toProlactin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toPd 1 connects-toVegf connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr connects-toEpinephrine