This is an auto-generated stub page built from atlas entry frontmatter. A richer
hand-crafted page is planned. See the
atlas source
for the full entry including detailed body sections.
generalized-anxiety-disorder
Generalized Anxiety Disorder
GAD (6% lifetime prevalence) is defined by 6+ months of excessive, uncontrollable worry; driven by HPA axis dysregulation, noradrenergic hyperactivity, and GABAergic deficit; SSRIs/SNRIs and duloxetine are first-line; buspirone and pregabalin are alternatives.
Entry Metadata
| Field | Value |
|---|---|
| ID | generalized-anxiety-disorder |
| Name | Generalized Anxiety Disorder |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toSerotonin
connects-toNorepinephrine
connects-toGaba
connects-toGlutamate
connects-toCortisol
connects-toBrain
connects-toSocial Anxiety Disorder
connects-toMajor Depressive Disorder
connects-toPanic Disorder
connects-toInsomnia Disorder
connects-toPtsd
connects-toHeart
connects-toObsessive Compulsive Disorder
connects-toBipolar Disorder
connects-toAlcohol Use Disorder
connects-toFibromyalgia
connects-toAsthma
connects-toMigraine
connects-toCrh
connects-toSerotonin Transporter
connects-toGut Microbiome
connects-toThyroid Hormones
connects-toDigestive System
connects-toHippocampus
connects-toThyroid
connects-toAdenosine
connects-toMicroglia
connects-toAdrenal Gland
connects-toMagnesium
connects-toEndocannabinoid
connects-toSynapse
connects-toLarge Intestine
connects-toNeuron
connects-toPhoton
connects-toAstrocyte
connects-toLung
connects-toZinc
connects-toStomach
connects-toVitamin D
connects-toMelatonin
connects-toSkin
connects-toReproductive System
connects-toIl 6
connects-toSmooth Muscle Cell
connects-toAtherosclerosis
connects-toBdnf
connects-toMast Cell
connects-toType 2 Diabetes
connects-toNlrp3 Inflammasome
connects-toOxytocin
connects-toHypertension
connects-toNf Kb
connects-toNervous System
connects-toCannabis Use Disorder
connects-toHeart Failure
connects-toStroke
connects-toObesity
connects-toCopd
connects-toAlzheimers Disease
connects-toOsteoporosis
connects-toEndocrine System
connects-toCardiovascular System
connects-toAttention Deficit Hyperactivity Disorder
connects-toMusculoskeletal System
connects-toImmune System
connects-toIntegumentary System
connects-toRespiratory System
connects-toFluoxetine
connects-toMagnesium Dietary
connects-toAshwagandha
connects-toOmega 3 Fatty Acids
connects-toInflammatory Bowel Disease
connects-toBeta Blockers
connects-toSt Johns Wort
connects-toBorderline Personality Disorder
connects-toNpy
connects-toGambling Disorder
connects-toCardiac Conduction System
connects-toEpilepsy
connects-toNeuropathic Pain
connects-toCovid 19 Disease
connects-toPheochromocytoma Paraganglioma
connects-toIntestinal Epithelium
connects-toMyocardium
connects-toIl 1B
connects-toTnf Alpha
connects-toDopamine
connects-toProgesterone
connects-toVasopressin
connects-toCcl2
connects-toEstrogen
connects-toSubstance P
connects-toHistamine
connects-toCgrp
connects-toOrexin
connects-toAcetylcholine
connects-toGlucocorticoid Receptor
connects-toIl 10
connects-toMtor
connects-toTlr4
connects-toNtrk
connects-toNfe2L2
connects-toAkt
connects-toMyd88
connects-toGalectin 3
connects-toGsk 3B
connects-toStat3
connects-toCgas Sting
connects-toFoxo
connects-toStat1
connects-toJak1 2
connects-toHif 1Alpha
connects-toS100A8 A9
connects-toPik3Ca
connects-toAmpk
connects-toAutophagy
connects-toDnmt3A
connects-toSrc Kinase
connects-toCcr5
connects-toCxcl12
connects-toIl 33
connects-toIl 17A
connects-toComplement C3
connects-toBeta1 Adrenergic Receptor
connects-toAngiotensin Ii
connects-toNitric Oxide
connects-toAldosterone
connects-toInsulin
connects-toTestosterone
connects-toProstaglandins
connects-toCholesterol
connects-toXanthine Oxidase
connects-toIl 4
connects-toIl 13
connects-toCopper
connects-toLeptin
connects-toAdiponectin
connects-toResistin
connects-toMicroglia
connects-toPanic Disorder
connects-toZinc
connects-toType I Interferon
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toT Cytotoxic Cell
connects-toNatural Killer Cell
connects-toC5Ar1
connects-toComplement C5
connects-toFactor H
connects-toDendritic Cell
connects-toTslp
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toErythropoietin
connects-toPeriostin
connects-toProlactin
connects-toSelenium
connects-toIodine
connects-toSodium
connects-toPotassium
connects-toPhosphorus
connects-toIron
connects-toCalcium
connects-toChloride
connects-toSulfur
connects-toNitrogen
connects-toCarbon
connects-toChloride
connects-toHydrogen
connects-toPd 1
connects-toGlp 1
connects-toVegf
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toTgf Beta
connects-toCalcitonin
connects-toInsulin Receptor
connects-toAndrogen Receptor
connects-toAdrenomedullin
connects-toOsteopontin
connects-toFgfr
connects-toEpinephrine
connects-toRenin
connects-toMyostatin
Sources
- Kessler RC, Berglund P, Demler O, et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593-602. · PubMed 15939837
- Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci. 2015;17(3):327-335. · PubMed 26487812
- Baldwin DS, Anderson IM, Nutt DJ, et al. Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology. J Psychopharmacol. 2014;28(5):403-439. · PubMed 24713617