Atlas One · Host Biology · Scale 07 — System

Generalized Anxiety Disorder

GAD (6% lifetime prevalence) is defined by 6+ months of excessive, uncontrollable worry; driven by HPA axis dysregulation, noradrenergic hyperactivity, and GABAergic deficit; SSRIs/SNRIs and duloxetine are first-line; buspirone and pregabalin are alternatives.

Also known as: GAD, generalized anxiety disorder, anxiety neurosis, chronic anxiety, free-floating anxiety, worry disorder

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
generalized-anxiety-disorder

Generalized Anxiety Disorder

GAD (6% lifetime prevalence) is defined by 6+ months of excessive, uncontrollable worry; driven by HPA axis dysregulation, noradrenergic hyperactivity, and GABAergic deficit; SSRIs/SNRIs and duloxetine are first-line; buspirone and pregabalin are alternatives.

Entry Metadata

FieldValue
IDgeneralized-anxiety-disorder
NameGeneralized Anxiety Disorder
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSerotonin connects-toNorepinephrine connects-toGaba connects-toGlutamate connects-toCortisol connects-toBrain connects-toSocial Anxiety Disorder connects-toMajor Depressive Disorder connects-toPanic Disorder connects-toInsomnia Disorder connects-toPtsd connects-toHeart connects-toObsessive Compulsive Disorder connects-toBipolar Disorder connects-toAlcohol Use Disorder connects-toFibromyalgia connects-toAsthma connects-toMigraine connects-toCrh connects-toSerotonin Transporter connects-toGut Microbiome connects-toThyroid Hormones connects-toDigestive System connects-toHippocampus connects-toThyroid connects-toAdenosine connects-toMicroglia connects-toAdrenal Gland connects-toMagnesium connects-toEndocannabinoid connects-toSynapse connects-toLarge Intestine connects-toNeuron connects-toPhoton connects-toAstrocyte connects-toLung connects-toZinc connects-toStomach connects-toVitamin D connects-toMelatonin connects-toSkin connects-toReproductive System connects-toIl 6 connects-toSmooth Muscle Cell connects-toAtherosclerosis connects-toBdnf connects-toMast Cell connects-toType 2 Diabetes connects-toNlrp3 Inflammasome connects-toOxytocin connects-toHypertension connects-toNf Kb connects-toNervous System connects-toCannabis Use Disorder connects-toHeart Failure connects-toStroke connects-toObesity connects-toCopd connects-toAlzheimers Disease connects-toOsteoporosis connects-toEndocrine System connects-toCardiovascular System connects-toAttention Deficit Hyperactivity Disorder connects-toMusculoskeletal System connects-toImmune System connects-toIntegumentary System connects-toRespiratory System connects-toFluoxetine connects-toMagnesium Dietary connects-toAshwagandha connects-toOmega 3 Fatty Acids connects-toInflammatory Bowel Disease connects-toBeta Blockers connects-toSt Johns Wort connects-toBorderline Personality Disorder connects-toNpy connects-toGambling Disorder connects-toCardiac Conduction System connects-toEpilepsy connects-toNeuropathic Pain connects-toCovid 19 Disease connects-toPheochromocytoma Paraganglioma connects-toIntestinal Epithelium connects-toMyocardium connects-toIl 1B connects-toTnf Alpha connects-toDopamine connects-toProgesterone connects-toVasopressin connects-toCcl2 connects-toEstrogen connects-toSubstance P connects-toHistamine connects-toCgrp connects-toOrexin connects-toAcetylcholine connects-toGlucocorticoid Receptor connects-toIl 10 connects-toMtor connects-toTlr4 connects-toNtrk connects-toNfe2L2 connects-toAkt connects-toMyd88 connects-toGalectin 3 connects-toGsk 3B connects-toStat3 connects-toCgas Sting connects-toFoxo connects-toStat1 connects-toJak1 2 connects-toHif 1Alpha connects-toS100A8 A9 connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toDnmt3A connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toBeta1 Adrenergic Receptor connects-toAngiotensin Ii connects-toNitric Oxide connects-toAldosterone connects-toInsulin connects-toTestosterone connects-toProstaglandins connects-toCholesterol connects-toXanthine Oxidase connects-toIl 4 connects-toIl 13 connects-toCopper connects-toLeptin connects-toAdiponectin connects-toResistin connects-toMicroglia connects-toPanic Disorder connects-toZinc connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Cytotoxic Cell connects-toNatural Killer Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toPeriostin connects-toProlactin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toPhosphorus connects-toIron connects-toCalcium connects-toChloride connects-toSulfur connects-toNitrogen connects-toCarbon connects-toChloride connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toVegf connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCalcitonin connects-toInsulin Receptor connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin