Atlas One · Host Biology · Scale 07 — System

Fibromyalgia

Fibromyalgia (2-3% prevalence, F:M 3:1) is a central sensitization disorder: SP-NMDA wind-up, descending serotonin/NE inhibition failure, reduced NAcc dopamine. Duloxetine, milnacipran (SNRIs), and pregabalin are FDA-approved; exercise and CBT are first-line.

Also known as: fibromyalgia, FM, fibromyalgia syndrome, FMS, central sensitization, chronic widespread pain, fibro fog, wind-up pain

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
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fibromyalgia

Fibromyalgia

Fibromyalgia (2-3% prevalence, F:M 3:1) is a central sensitization disorder: SP-NMDA wind-up, descending serotonin/NE inhibition failure, reduced NAcc dopamine. Duloxetine, milnacipran (SNRIs), and pregabalin are FDA-approved; exercise and CBT are first-line.

Entry Metadata

FieldValue
IDfibromyalgia
NameFibromyalgia
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toGlutamate connects-toSerotonin connects-toNorepinephrine connects-toDopamine connects-toSubstance P targetsBrain connects-toCgrp connects-toNeuropathic Pain

Sources