Atlas One · Host Biology · Scale 07 — System

Fibromyalgia

Fibromyalgia (2-3% prevalence, F:M 3:1) is a central sensitization disorder: SP-NMDA wind-up, descending serotonin/NE inhibition failure, reduced NAcc dopamine. Duloxetine, milnacipran (SNRIs), and pregabalin are FDA-approved; exercise and CBT are first-line.

Also known as: fibromyalgia, FM, fibromyalgia syndrome, FMS, central sensitization, chronic widespread pain, fibro fog, wind-up pain

Scale 07 — SystemScale

draftStatus

2026-06-08Last Reviewed

This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.

fibromyalgia

Fibromyalgia

Fibromyalgia (2-3% prevalence, F:M 3:1) is a central sensitization disorder: SP-NMDA wind-up, descending serotonin/NE inhibition failure, reduced NAcc dopamine. Duloxetine, milnacipran (SNRIs), and pregabalin are FDA-approved; exercise and CBT are first-line.

Entry Metadata

Field	Value
ID	fibromyalgia
Name	Fibromyalgia
Status	draft
Last reviewed	2026-06-08
Atlas	01-human
Scale	07-system

Cross-Atlas Connections

connects-toGlutamate connects-toSerotonin connects-toNorepinephrine connects-toDopamine connects-toSubstance P targetsBrain connects-toCgrp connects-toNeuropathic Pain connects-toMigraine connects-toMajor Depressive Disorder connects-toGeneralized Anxiety Disorder connects-toPtsd connects-toRheumatoid Arthritis connects-toSjogrens Syndrome connects-toGut Microbiome connects-toSystemic Lupus Erythematosus connects-toHippocampus connects-toInsomnia Disorder connects-toNeuron connects-toCortisol connects-toMicroglia connects-toGaba connects-toPeripheral Nerve connects-toThyroid connects-toVitamin D connects-toCalcium connects-toMagnesium connects-toAstrocyte connects-toGrowth Hormone connects-toSynapse connects-toLarge Intestine connects-toMast Cell connects-toPhoton connects-toSkin connects-toBdnf connects-toMu Opioid Receptor connects-toHeart connects-toSodium connects-toMelatonin connects-toStomach connects-toAdenosine connects-toEndocannabinoid connects-toReproductive System connects-toSmall Intestine connects-toEstrogen connects-toT Helper Cell connects-toObesity connects-toNervous System connects-toNlrp3 Inflammasome connects-toNatural Killer Cell connects-toIl 6 connects-toMusculoskeletal System connects-toPanic Disorder connects-toOpioid Use Disorder connects-toAttention Deficit Hyperactivity Disorder connects-toBorderline Personality Disorder connects-toBipolar Disorder connects-toPsoriatic Arthritis connects-toType 2 Diabetes connects-toDigestive System connects-toRenal System connects-toEndocrine System connects-toIntegumentary System connects-toImmune System connects-toCardiovascular System connects-toRespiratory System connects-toCovid 19 Disease connects-toMagnesium Dietary connects-toFluoxetine connects-toEpstein Barr Virus connects-toAshwagandha connects-toCannabis Use Disorder connects-toPanax Ginseng connects-toCancer Chemotherapy connects-toAnkylosing Spondylitis connects-toNarcolepsy connects-toEpilepsy connects-toSystemic Sclerosis connects-toSocial Anxiety Disorder connects-toTnf Alpha connects-toIntestinal Epithelium connects-toCardiac Conduction System connects-toObsessive Compulsive Disorder connects-toNpy connects-toLeptin connects-toIl 1B connects-toSerotonin Transporter connects-toOxytocin connects-toNitric Oxide connects-toIgf 1 connects-toTlr4 connects-toNtrk connects-toOrexin connects-toHistamine connects-toAcetylcholine connects-toCrh connects-toGlucocorticoid Receptor connects-toIl 10 connects-toErk1 2 connects-toActh connects-toMyd88 connects-toNf Kb connects-toNfe2L2 connects-toJak1 2 connects-toGsk 3B connects-toStat3 connects-toGalectin 3 connects-toStat1 connects-toCgas Sting connects-toFoxo connects-toAkt connects-toHif 1Alpha connects-toS100A8 A9 connects-toPik3Ca connects-toMtor connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toDnmt3A connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toThyroid Hormones connects-toProgesterone connects-toXanthine Oxidase connects-toAngiotensin Ii connects-toInsulin connects-toAldosterone connects-toProstaglandins connects-toVasopressin connects-toIl 17A connects-toIl 4 connects-toZinc connects-toCopper connects-toIl 13 connects-toAdiponectin connects-toResistin connects-toMajor Depressive Disorder connects-toMast Cell connects-toZinc connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Cytotoxic Cell connects-toDendritic Cell connects-toSelenium connects-toComplement C3 connects-toC5Ar1 connects-toFactor H connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toComplement C5 connects-toTestosterone connects-toProlactin connects-toTransferrin connects-toIodine connects-toPotassium connects-toPhosphorus connects-toIron connects-toChloride connects-toSulfur connects-toNitrogen connects-toOxygen connects-toCarbon connects-toChloride connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toVegf connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toActivin A connects-toTgf Beta connects-toCalcitonin connects-toInsulin Receptor connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin

Sources