Atlas One · Host Biology · Scale 07 — System

Systemic Lupus Erythematosus

Systemic autoimmune disease from loss of tolerance to nucleic acid antigens; type I IFN signature and complement activation define pathogenesis. Anti-dsDNA and low complement are diagnostic. Hydroxychloroquine is mainstay; belimumab and anifrolumab are approved biologics.

Also known as: SLE, lupus, systemic lupus, lupus erythematosus, LN, lupus nephritis

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
systemic-lupus-erythematosus

Systemic Lupus Erythematosus

Systemic autoimmune disease from loss of tolerance to nucleic acid antigens; type I IFN signature and complement activation define pathogenesis. Anti-dsDNA and low complement are diagnostic. Hydroxychloroquine is mainstay; belimumab and anifrolumab are approved biologics.

Entry Metadata

FieldValue
IDsystemic-lupus-erythematosus
NameSystemic Lupus Erythematosus
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toComplement C3 connects-toT Helper Cell connects-toNlrp3 Inflammasome connects-toNf Kb connects-toType I Interferon connects-toFcrn connects-toCalcineurin connects-toC5Ar1 connects-toBeta2 Glycoprotein 1 connects-toAntiphospholipid Syndrome connects-toCgas Sting connects-toSjogrens Syndrome connects-toCkd connects-toPlasma Cell connects-toRheumatoid Arthritis connects-toB Cell connects-toImmune Thrombocytopenia connects-toKidney connects-toDendritic Cell connects-toImmunoglobulin G connects-toSkin connects-toBrain connects-toNeutrophil connects-toGlomerulus connects-toPlacenta connects-toRegulatory T Cell connects-toPhoton connects-toMacrophage connects-toEstrogen connects-toHeart connects-toCalcium connects-toErythrocyte connects-toLung connects-toPotassium connects-toPeripheral Nerve connects-toElectron connects-toEye connects-toVitamin D connects-toAntibody connects-toNeuron connects-toPlatelet connects-toReproductive System connects-toEndothelial Cell connects-toLarge Intestine connects-toBaff connects-toEpstein Barr Virus connects-toPodocyte connects-toJak1 2 connects-toAtherosclerosis connects-toNervous System connects-toStat3 connects-toVenous Thromboembolism connects-toSepsis connects-toAnemia Of Chronic Disease connects-toPneumocystis Jirovecii connects-toOsteoporosis connects-toPulmonary Arterial Hypertension connects-toStroke connects-toTuberculosis connects-toIntegumentary System connects-toVaricella Zoster Virus connects-toDigestive System connects-toImmune System connects-toMusculoskeletal System connects-toCardiovascular System connects-toRenal System connects-toRespiratory System connects-toLymphatic System connects-toEndocrine System connects-toCorticosteroids connects-toWarfarin connects-toCancer Chemotherapy connects-toTargeted Therapy connects-toArterial Wall connects-toGerminal Center connects-toEndocardium connects-toNmo connects-toDlbcl connects-toDermatomyositis connects-toMyocardium connects-toCardiac Conduction System connects-toCytokine Storm connects-toEpilepsy connects-toIl 6 connects-toIfn Gamma connects-toNatural Killer Cell connects-toS100A8 A9 connects-toIl 17A connects-toMhc Class Ii connects-toCd20 connects-toCcl2 connects-toRig I connects-toIl 2 connects-toGlucocorticoid Receptor connects-toDnmt3A connects-toIrf3 connects-toComplement C5 connects-toCaspase 3 connects-toMyd88 connects-toStat1 connects-toCtla 4 connects-toAkt connects-toMtor connects-toIl 10 connects-toGalectin 3 connects-toSmad4 connects-toPerforin connects-toFoxo connects-toErk1 2 connects-toHif 1Alpha connects-toGsk 3B connects-toPik3Ca connects-toSrc Kinase connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toIl 1B connects-toArid1A connects-toAdenosine connects-toOsteopontin connects-toNitric Oxide connects-toProlactin connects-toBcl 2 connects-toHemoglobin connects-toIl 4 connects-toTroponin Complex connects-toCholesterol connects-toProstaglandins connects-toXanthine Oxidase connects-toHepcidin connects-toIron connects-toOmega 3 Fatty Acids connects-toIl 13 connects-toLeptin connects-toResistin connects-toAdiponectin connects-toMacrophage connects-toNmo connects-toSystemic Sclerosis connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toFactor H connects-toT Cytotoxic Cell connects-toSelenium connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toOxytocin connects-toTestosterone connects-toSerotonin connects-toVasopressin connects-toIodine connects-toSodium connects-toMagnesium connects-toZinc connects-toCopper connects-toPhosphorus connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toVegf connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf