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systemic-lupus-erythematosus
Systemic Lupus Erythematosus
Systemic autoimmune disease from loss of tolerance to nucleic acid antigens; type I IFN signature and complement activation define pathogenesis. Anti-dsDNA and low complement are diagnostic. Hydroxychloroquine is mainstay; belimumab and anifrolumab are approved biologics.
Entry Metadata
| Field | Value |
|---|---|
| ID | systemic-lupus-erythematosus |
| Name | Systemic Lupus Erythematosus |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toComplement C3
connects-toT Helper Cell
connects-toNlrp3 Inflammasome
connects-toNf Kb
connects-toType I Interferon
connects-toFcrn
connects-toCalcineurin
connects-toC5Ar1
connects-toBeta2 Glycoprotein 1
connects-toAntiphospholipid Syndrome
connects-toCgas Sting
connects-toSjogrens Syndrome
connects-toCkd
connects-toPlasma Cell
connects-toRheumatoid Arthritis
connects-toB Cell
connects-toImmune Thrombocytopenia
connects-toKidney
connects-toDendritic Cell
connects-toImmunoglobulin G
connects-toSkin
connects-toBrain
connects-toNeutrophil
connects-toGlomerulus
connects-toPlacenta
connects-toRegulatory T Cell
connects-toPhoton
connects-toMacrophage
connects-toEstrogen
connects-toHeart
connects-toCalcium
connects-toErythrocyte
connects-toLung
connects-toPotassium
connects-toPeripheral Nerve
connects-toElectron
connects-toEye
connects-toVitamin D
connects-toAntibody
connects-toNeuron
connects-toPlatelet
connects-toReproductive System
connects-toEndothelial Cell
connects-toLarge Intestine
connects-toBaff
connects-toEpstein Barr Virus
connects-toPodocyte
connects-toJak1 2
connects-toAtherosclerosis
connects-toNervous System
connects-toStat3
connects-toVenous Thromboembolism
connects-toSepsis
connects-toAnemia Of Chronic Disease
connects-toPneumocystis Jirovecii
connects-toOsteoporosis
connects-toPulmonary Arterial Hypertension
connects-toStroke
connects-toTuberculosis
connects-toIntegumentary System
connects-toVaricella Zoster Virus
connects-toDigestive System
connects-toImmune System
connects-toMusculoskeletal System
connects-toCardiovascular System
connects-toRenal System
connects-toRespiratory System
connects-toLymphatic System
connects-toEndocrine System
connects-toCorticosteroids
connects-toWarfarin
connects-toCancer Chemotherapy
connects-toTargeted Therapy
connects-toArterial Wall
connects-toGerminal Center
connects-toEndocardium
connects-toNmo
connects-toDlbcl
connects-toDermatomyositis
connects-toMyocardium
connects-toCardiac Conduction System
connects-toCytokine Storm
connects-toEpilepsy
connects-toIl 6
connects-toIfn Gamma
connects-toNatural Killer Cell
connects-toS100A8 A9
connects-toIl 17A
connects-toMhc Class Ii
connects-toCd20
connects-toCcl2
connects-toRig I
connects-toIl 2
connects-toGlucocorticoid Receptor
connects-toDnmt3A
connects-toIrf3
connects-toComplement C5
connects-toCaspase 3
connects-toMyd88
connects-toStat1
connects-toCtla 4
connects-toAkt
connects-toMtor
connects-toIl 10
connects-toGalectin 3
connects-toSmad4
connects-toPerforin
connects-toFoxo
connects-toErk1 2
connects-toHif 1Alpha
connects-toGsk 3B
connects-toPik3Ca
connects-toSrc Kinase
connects-toAmpk
connects-toAutophagy
connects-toCcr5
connects-toCxcl12
connects-toIl 33
connects-toIl 1B
connects-toArid1A
connects-toAdenosine
connects-toOsteopontin
connects-toNitric Oxide
connects-toProlactin
connects-toBcl 2
connects-toHemoglobin
connects-toIl 4
connects-toTroponin Complex
connects-toCholesterol
connects-toProstaglandins
connects-toXanthine Oxidase
connects-toHepcidin
connects-toIron
connects-toOmega 3 Fatty Acids
connects-toIl 13
connects-toLeptin
connects-toResistin
connects-toAdiponectin
connects-toMacrophage
connects-toNmo
connects-toSystemic Sclerosis
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toMast Cell
connects-toFactor H
connects-toT Cytotoxic Cell
connects-toSelenium
connects-toC1 Esterase Inhibitor
connects-toPeriostin
connects-toTransferrin
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toHistamine
connects-toMelatonin
connects-toOxytocin
connects-toTestosterone
connects-toSerotonin
connects-toVasopressin
connects-toIodine
connects-toSodium
connects-toMagnesium
connects-toZinc
connects-toCopper
connects-toPhosphorus
connects-toChloride
connects-toSulfur
connects-toCarbon
connects-toHydrogen
connects-toNitrogen
connects-toOxygen
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toRankl
connects-toVegf
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toTgf Beta
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
Sources
- Tsokos GC. Systemic lupus erythematosus. N Engl J Med. 2011;365(22):2110-2121. · PubMed 22129253
- Furie R, Petri M, Zamani O, et al. A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus. Arthritis Rheum. 2011;63(12):3918-3930. · PubMed 22127708
- Morand EF, Furie R, Tanaka Y, et al. Trial of anifrolumab in active systemic lupus erythematosus. N Engl J Med. 2020;382(3):211-221. · PubMed 31851795