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gsk-3b
GSK-3β
GSK-3β (glycogen synthase kinase 3 beta), a constitutively active Ser/Thr kinase, phosphorylates glycogen synthase, tau, and β-catenin; inhibited by lithium (gold-standard mood stabilizer) and Wnt signaling; implicated in bipolar disorder, Alzheimer's tau pathology, and cancer.
Entry Metadata
| Field | Value |
|---|---|
| ID | gsk-3b |
| Name | GSK-3β |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Woodgett JR. Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J. 1990;9(8):2431-2438. · PubMed 2164468
- Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA. 1996;93(16):8455-8459. · PubMed 8710892
- Beurel E, Grieco SF, Jope RS. Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. Pharmacol Ther. 2015;148:114-131. · PubMed 25435019