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mapt
MAPT
MAPT encodes tau, a microtubule-stabilizing protein; CDK5 and GSK-3β hyperphosphorylate tau → detachment from microtubules → neurofibrillary tangles; tau Braak staging (I–VI) correlates with cognitive decline in Alzheimer disease and other tauopathies.
Entry Metadata
| Field | Value |
|---|---|
| ID | mapt |
| Name | MAPT |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA. 1986;83(13):4913-4917. · PubMed 3088567
- Iqbal K, Liu F, Gong CX. Tau and neurodegenerative disease: the story so far. Nat Rev Neurol. 2016;12(1):15-27. · PubMed 26635213