Atlas One · Host Biology · Scale 03 — Molecular

APP

APP encodes amyloid precursor protein; β/γ-secretase cleavage releases Aβ42 peptides that aggregate into plaques; FAD mutations and trisomy 21 increase Aβ42; amyloid accumulation drives synaptic loss and neurodegeneration; lecanemab (anti-Aβ antibody) slows AD progression 27%.

Also known as: APP, amyloid precursor protein, amyloid beta, Aβ, Aβ42, A-beta, ABPP, FAD APP mutations, amyloid hypothesis target

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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app

APP

APP encodes amyloid precursor protein; β/γ-secretase cleavage releases Aβ42 peptides that aggregate into plaques; FAD mutations and trisomy 21 increase Aβ42; amyloid accumulation drives synaptic loss and neurodegeneration; lecanemab (anti-Aβ antibody) slows AD progression 27%.

Entry Metadata

FieldValue
IDapp
NameAPP
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toAlzheimers Disease connects-toApoe connects-toNlrp3 Inflammasome connects-toMtor

Sources