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nlrp3-inflammasome
NLRP3 Inflammasome
Cytosolic multiprotein danger-sensing complex (NLRP3/ASC/caspase-1) activated by PAMPs and DAMPs. Processes pro-IL-1β and pro-IL-18 to active cytokines and triggers pyroptosis via gasdermin D pore formation.
Entry Metadata
| Field | Value |
|---|---|
| ID | nlrp3-inflammasome |
| Name | NLRP3 Inflammasome |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10(2):417-426. · PubMed 12191486
- Swanson KV, Deng M, Ting JP. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019;19(8):477-489. · PubMed 31036962
- Duewell P, Kono H, Rayner KJ, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010;464(7293):1357-1361. · PubMed 20428172
- Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660-665. · PubMed 26375003