Atlas One · Host Biology · Scale 03 — Molecular

NF-κB

Master transcription factor of inflammation. IKKβ phosphorylates IκBα → proteasomal degradation → p65/p50 nuclear translocation → TNF-α, IL-6, IL-1β, COX-2 transcription. Activated by LPS, TNF-α, IL-1β, oxidative stress, and viral dsRNA.

Also known as: NF-κB, nuclear factor kappa B, NFKB, p65/p50, RelA/p50, NF-kB

Scale 03 — MolecularScale
draftStatus
2026-06-05Last Reviewed
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nf-kb

NF-κB

Master transcription factor of inflammation. IKKβ phosphorylates IκBα → proteasomal degradation → p65/p50 nuclear translocation → TNF-α, IL-6, IL-1β, COX-2 transcription. Activated by LPS, TNF-α, IL-1β, oxidative stress, and viral dsRNA.

Entry Metadata

FieldValue
IDnf-kb
NameNF-κB
Statusdraft
Last reviewed2026-06-05
Atlas01-human
Scale03-molecular
Gene SymbolRELA
UniprotQ04206

Cross-Atlas Connections

modulatesTnf Alpha modulatesIl 6 modulatesMacrophage modulated-byCurcumin modulated-byNitric Oxide modulated-byProstaglandins modulated-byZika Virus modulated-bySulforaphane modulated-byResveratrol modulated-byQuercetin modulated-byMilk Thistle connects-toType I Interferon modulated-byIl 36 connects-toBaff connects-toIl 1B connects-toTlr4 connects-toCgas Sting connects-toIrf3 connects-toTbk1 connects-toHepatitis B connects-toEpstein Barr Virus connects-toLmp1 connects-toHiv connects-toHiv Gp120 connects-toSars Cov 2 connects-toSars Cov 2 Spike connects-toAicardi Goutieres Syndrome

Sources