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hiv
HIV
HIV (HIV-1; lentivirus; ~10 kb ssRNA) causes AIDS by depleting CD4+ T cells; CCR5/CXCR4 co-receptor tropism; reverse transcription → proviral integration → latency; ART (NRTI/NNRTI/PI/InSTI) controls but cannot cure; ~39 million people live with HIV globally.
Entry Metadata
| Field | Value |
|---|---|
| ID | hiv |
| Name | HIV |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Barré-Sinoussi F, Chermann JC, Rey F, et al. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. 1983;220(4599):868-871. · PubMed 6189183
- Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature. 1995;373(6510):123-126. · PubMed 7816094
- Siliciano JD, Kajdas J, Finzi D, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med. 2003;9(6):727-728. · PubMed 12754504