Human Immunodeficiency Virus type 1

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hiv-1

Human Immunodeficiency Virus type 1

Lentivirus (Retroviridae). ~9.7 kb diploid ssRNA genome. CD4-tropic; gp120/gp41-mediated entry; reverse transcriptase drives rapid diversification; proviral integration establishes latent reservoir; causes AIDS via CD4+ T cell depletion.

Entry Metadata

Field	Value
ID	hiv-1
Name	Human Immunodeficiency Virus type 1
Status	active
Last reviewed	2026-06-04
Class	01-viruses
Family	Retroviridae
Genus	Lentivirus
Species	HIV-1

Cross-Atlas Connections

infectsT Helper Cell infectsDendritic Cell damagesImmune System damagesT Helper Cell target-ofImmunoglobulin G connects-toAicardi Goutieres Syndrome co-factorHpv 16

Sources

Gallo RC, Salahuddin SZ, Popovic M, et al. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 1984;224(4648):500-3. · PubMed 6200935
Chun TW, Stuyver L, Mizell SB, et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci USA. 1997;94(24):13193-7. · PubMed 9353114
Lundgren JD, Babiker AG, Gordin F, et al. Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection (START). N Engl J Med. 2015;373(9):795-807.