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hpv-16
HPV-16
Double-stranded DNA papillomavirus (~8 kb). E6 degrades p53 via E6AP ubiquitin ligase; E7 binds Rb family, releasing E2F and deregulating the cell cycle. Causative in 50-60% of cervical cancers and oropharyngeal, anal, vulvar, and penile malignancies. Preventable by Gardasil-9.
Entry Metadata
| Field | Value |
|---|---|
| ID | hpv-16 |
| Name | HPV-16 |
| Status | active |
| Last reviewed | 2026-06-05 |
| Class | 01-viruses |
| Family | Papillomaviridae |
| Genus | Alphapapillomavirus |
| Species | Human papillomavirus type 16 |
Cross-Atlas Connections
Sources
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- Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet. 2007;370(9590):890-907. · PubMed 17826171
- Munger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley PM. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 1989;8(13):4099-105. · PubMed 2556261
- Schiller JT, Castellsague X, Garland SM. A review of clinical trials of human papillomavirus prophylactic vaccines. Vaccine. 2012;30(Suppl 5):F123-38. · PubMed 23199956
- Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-249. · PubMed 33538338
- Stanley M. Immunobiology of HPV and HPV vaccines. Gynecol Oncol. 2010;118(1 Suppl):S12-6. · PubMed 20494223