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dendritic-cell
Dendritic Cell
Professional antigen-presenting cell bridging innate and adaptive immunity. Immature DCs patrol tissues; mature DCs upregulate MHC-II and migrate to lymph nodes to prime T cells. Two major subsets: cDC1/cDC2 and pDC.
Entry Metadata
| Field | Value |
|---|---|
| ID | dendritic-cell |
| Name | Dendritic Cell |
| Status | draft |
| Last reviewed | 2026-06-04 |
| Atlas | 01-human |
| Scale | 04-cellular |
Cross-Atlas Connections
part-ofImmune System
expressesMhc Class Ii
modulatesT Helper Cell
infected-bySars Cov 2
infected-byHiv 1
infected-byDengue Virus
modulated-byNatural Killer Cell
modulated-byIntestinal Epithelium
damaged-byStaphylococcus Aureus
damaged-byAspergillus Fumigatus
infected-byCandida Albicans
part-ofThymus
infected-byHpv 16
modulated-byHistamine
part-ofIntegumentary System
modulated-byT Cytotoxic Cell
damaged-byNorovirus
infected-byEpstein Barr Virus
infected-byMeasles Virus
damaged-byGiardia Lamblia
connects-toMv H Protein
connects-toMeasles
Sources
- Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392(6673):245-52. · PubMed 9521319
- Merad M, Sathe P, Helft J, Miller J, Mortha A. The dendritic cell lineage: ontogeny and function of dendritic cells and their precursors in steady state and the inflamed setting. Annu Rev Immunol. 2013;31:563-604. · PubMed 23516985
- Guilliams M, et al. Dendritic cells and monocytes with distinct inflammatory responses reside in lung mucosa of mild COVID-19 patients. J Exp Med. 2020;217(12):e20201228. · PubMed 33027508
- Steinman RM. Dendritic cells: understanding immunogenicity. Eur J Immunol. 2007;37 Suppl 1:S53-60. · PubMed 17972355