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norovirus-vp1
Norovirus VP1
Norovirus VP1 (530 aa; T=3 icosahedral; 90 dimers) is the major capsid protein with S-domain (inner shell) and P-domain (P1/P2); P2 subdomain binds HBGAs (FUT2 H antigen) and carries all major neutralizing epitopes; GII.4 P2 antigenic drift drives pandemic emergence.
Entry Metadata
| Field | Value |
|---|---|
| ID | norovirus-vp1 |
| Name | Norovirus VP1 |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Prasad BVV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK. X-ray crystallographic structure of the Norwalk virus capsid. Science. 1999;286(5438):287-290. · PubMed 10514371
- Tan M, Jiang X. Norovirus and its histo-blood group antigen receptors: an answer to a historical puzzle. Trends Microbiol. 2005;13(6):285-293. · PubMed 15936186
- Lindesmith LC, Costantini V, Swanstrom J, et al. Emergence of a norovirus GII.4 strain correlates with changes in evolving blockade epitopes. J Virol. 2008;82(23):11648-11660. · PubMed 18842720
- Atmar RL, Bernstein DI, Harro CD, et al. Norovirus vaccine against experimental human GI.1 illness. N Engl J Med. 2011;365(23):2178-2187. · PubMed 22150036