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rsv-f-protein
RSV F Protein
RSV fusion (F) protein (class I viral fusogen; 574 aa; pre-F and post-F conformations) mediates RSV-host membrane fusion → syncytia; prefusion site Ø is the dominant neutralizing epitope targeted by nirsevimab and mRNA vaccines; DS-Cav1 proline locks F in prefusion for vaccines.
Entry Metadata
| Field | Value |
|---|---|
| ID | rsv-f-protein |
| Name | RSV F Protein |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- McLellan JS, Chen M, Leung S, et al. Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science. 2013;342(6158):592-598. · PubMed 23618766
- Mazur NI, Higgins D, Nunes MC, et al. The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates. Lancet Infect Dis. 2018;18(10):e295-e311. · PubMed 29954680