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tslp
TSLP
TSLP (TSLP, chr5q22.1) is an epithelial alarmin activating DCs and ILC2 upstream of the Th2 cascade; TSLPR/IL-7Rα → JAK1/JAK2 → STAT5; tezepelumab (anti-TSLP mAb) reduces severe asthma exacerbations 70% (NAVIGATOR) — effective irrespective of eosinophil count.
Entry Metadata
| Field | Value |
|---|---|
| ID | tslp |
| Name | TSLP |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Corren J, Menzies-Gow A, Harris JM, et al. Tezepelumab in adults with severe, uncontrolled asthma (NAVIGATOR): a phase 3 trial. N Engl J Med. 2021;384(19):1800-1809. · PubMed 33979488
- Liu YJ. Thymic stromal lymphopoietin: master switch for allergic inflammation. J Exp Med. 2006;203(2):269-273. · PubMed 16476766