Atlas One · Host Biology · Scale 07 — System

Prurigo Nodularis

Prurigo nodularis is a chronic neuro-inflammatory skin disease with hyperkeratotic nodules driven by an itch-scratch cycle; Th2/Th22 inflammation and IL-31/IL-4/IL-13 signaling; nemolizumab (anti-IL-31RA) and dupilumab (anti-IL-4Rα) are FDA-approved treatments.

Also known as: PN, prurigo nodularis Hyde, nodular prurigo, chronic prurigo, lichen obtusus

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
prurigo-nodularis

Prurigo Nodularis

Prurigo nodularis is a chronic neuro-inflammatory skin disease with hyperkeratotic nodules driven by an itch-scratch cycle; Th2/Th22 inflammation and IL-31/IL-4/IL-13 signaling; nemolizumab (anti-IL-31RA) and dupilumab (anti-IL-4Rα) are FDA-approved treatments.

Entry Metadata

FieldValue
IDprurigo-nodularis
NamePrurigo Nodularis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toIl 31 connects-toAtopic Dermatitis connects-toIl 4 connects-toTslp connects-toSubstance P connects-toCkd connects-toSkin connects-toNeuron connects-toMast Cell connects-toNeuropathic Pain connects-toPsoriasis connects-toHiv Aids connects-toT Helper Cell connects-toMajor Depressive Disorder connects-toDendritic Cell connects-toHistamine connects-toIl 13 connects-toInsomnia Disorder connects-toJak1 2 connects-toIntegumentary System connects-toNervous System connects-toLiver connects-toHodgkin Lymphoma connects-toFibroblast connects-toMu Opioid Receptor connects-toThyroid connects-toType 2 Diabetes connects-toIl 17A connects-toRegulatory T Cell connects-toCollagen connects-toPhoton connects-toFibrosis connects-toKidney connects-toIron connects-toBrain connects-toPeripheral Nerve connects-toElectron connects-toVitamin D connects-toZinc connects-toAntibody connects-toEye connects-toNeutrophil connects-toEndocannabinoid connects-toGut Microbiome connects-toErythrocyte connects-toHepatitis C connects-toCgrp connects-toMacrophage connects-toIl 5 connects-toIl 33 connects-toGeneralized Anxiety Disorder connects-toStat3 connects-toNf Kb connects-toOpioid Use Disorder connects-toHiv connects-toObsessive Compulsive Disorder connects-toHcc connects-toStaphylococcus Aureus connects-toWound Healing connects-toDlbcl connects-toImmune System connects-toEndocrine System connects-toIron Deficiency Anemia connects-toRespiratory System connects-toLymphatic System connects-toReproductive System connects-toDigestive System connects-toCardiovascular System connects-toMusculoskeletal System connects-toRenal System connects-toCorticosteroids connects-toCholangiocarcinoma connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toDermatomyositis connects-toAsthma connects-toPolycythemia Vera connects-toBdnf connects-toMyelofibrosis connects-toPancreatic Cancer connects-toPtsd connects-toPtcl connects-toSocial Anxiety Disorder connects-toCovid 19 Disease connects-toPeriostin connects-toTnf Alpha connects-toIl 6 connects-toCcl2 connects-toPdgf connects-toSerotonin connects-toNtrk connects-toKit connects-toIl 1B connects-toTgf Beta connects-toGlutamate connects-toProstaglandins connects-toIl 10 connects-toNlrp3 Inflammasome connects-toIl 2 connects-toMtor connects-toTlr4 connects-toErk1 2 connects-toAkt connects-toSmad4 connects-toGalectin 3 connects-toStat1 connects-toCgas Sting connects-toPik3Ca connects-toFoxo connects-toS100A8 A9 connects-toHif 1Alpha connects-toGsk 3B connects-toSrc Kinase connects-toPerforin connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toComplement C3 connects-toArid1A connects-toCalcineurin connects-toAdenosine connects-toCalcium connects-toNitric Oxide connects-toThyroid Hormones connects-toVegf connects-toXanthine Oxidase connects-toLeptin connects-toCholesterol connects-toInsulin connects-toCortisol connects-toT Helper Cell connects-toNeuron connects-toCkd connects-toAdiponectin connects-toResistin connects-toGastric Cancer connects-toMast Cell connects-toT Helper Cell connects-toCkd connects-toIge connects-toIfn Gamma connects-toIl 12 connects-toIl 23 connects-toType I Interferon connects-toPlasma Cell connects-toT Cytotoxic Cell connects-toNatural Killer Cell connects-toRsv connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toTransferrin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCalcitonin connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr connects-toEpinephrine

Sources