Atlas One · Host Biology · Scale 07 — System

Prurigo Nodularis

Prurigo nodularis is a chronic neuro-inflammatory skin disease with hyperkeratotic nodules driven by an itch-scratch cycle; Th2/Th22 inflammation and IL-31/IL-4/IL-13 signaling; nemolizumab (anti-IL-31RA) and dupilumab (anti-IL-4Rα) are FDA-approved treatments.

Also known as: PN, prurigo nodularis Hyde, nodular prurigo, chronic prurigo, lichen obtusus

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
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prurigo-nodularis

Prurigo Nodularis

Prurigo nodularis is a chronic neuro-inflammatory skin disease with hyperkeratotic nodules driven by an itch-scratch cycle; Th2/Th22 inflammation and IL-31/IL-4/IL-13 signaling; nemolizumab (anti-IL-31RA) and dupilumab (anti-IL-4Rα) are FDA-approved treatments.

Entry Metadata

FieldValue
IDprurigo-nodularis
NamePrurigo Nodularis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toIl 31 connects-toAtopic Dermatitis connects-toIl 4 connects-toTslp connects-toSubstance P connects-toCkd connects-toSkin connects-toNeuron connects-toMast Cell connects-toNeuropathic Pain connects-toPsoriasis connects-toHiv Aids

Sources