Atlas One · Host Biology · Scale 07 — System

Hepatitis C

HCV (Hepacivirus; positive-sense ssRNA; genotypes 1-6) infects 58M people globally; NS3/4A cleaves MAVS → IRF3 not activated → chronicity in 80%; direct-acting antivirals (SOF/VEL, GLE/PIB) achieve >95% cure; cirrhosis → HCC risk 1-5%/year; no vaccine exists.

Also known as: HCV, hepatitis C virus, chronic hepatitis C, HCV cirrhosis, HCV RNA, NS3/4A, sofosbuvir, DAA, direct-acting antiviral, Epclusa, Mavyret, HCV genotype, Hepacivirus

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hepatitis-c

Hepatitis C

HCV (Hepacivirus; positive-sense ssRNA; genotypes 1-6) infects 58M people globally; NS3/4A cleaves MAVS → IRF3 not activated → chronicity in 80%; direct-acting antivirals (SOF/VEL, GLE/PIB) achieve >95% cure; cirrhosis → HCC risk 1-5%/year; no vaccine exists.

Entry Metadata

FieldValue
IDhepatitis-c
NameHepatitis C
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMavs connects-toIrf3 connects-toType I Interferon connects-toStat1 connects-toHcc

Sources