Atlas One · Host Biology · Scale 07 — System

Hepatitis C

HCV (Hepacivirus; positive-sense ssRNA; genotypes 1-6) infects 58M people globally; NS3/4A cleaves MAVS → IRF3 not activated → chronicity in 80%; direct-acting antivirals (SOF/VEL, GLE/PIB) achieve >95% cure; cirrhosis → HCC risk 1-5%/year; no vaccine exists.

Also known as: HCV, hepatitis C virus, chronic hepatitis C, HCV cirrhosis, HCV RNA, NS3/4A, sofosbuvir, DAA, direct-acting antiviral, Epclusa, Mavyret, HCV genotype, Hepacivirus

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hepatitis-c

Hepatitis C

HCV (Hepacivirus; positive-sense ssRNA; genotypes 1-6) infects 58M people globally; NS3/4A cleaves MAVS → IRF3 not activated → chronicity in 80%; direct-acting antivirals (SOF/VEL, GLE/PIB) achieve >95% cure; cirrhosis → HCC risk 1-5%/year; no vaccine exists.

Entry Metadata

FieldValue
IDhepatitis-c
NameHepatitis C
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMavs connects-toIrf3 connects-toType I Interferon connects-toStat1 connects-toHcc connects-toHepatitis C Virus connects-toLiver connects-toB Cell connects-toHepatitis B connects-toTgf Beta connects-toType 2 Diabetes connects-toHiv Aids connects-toFollicular Lymphoma connects-toHepatocyte connects-toDlbcl connects-toCkd connects-toSjogrens Syndrome connects-toT Cytotoxic Cell connects-toNash connects-toRheumatoid Arthritis connects-toFibrosis connects-toSkin connects-toNatural Killer Cell connects-toGlomerulus connects-toComplement C3 connects-toT Helper Cell connects-toCholesterol connects-toIron connects-toMacrophage connects-toOxygen connects-toDendritic Cell connects-toLarge Intestine connects-toPhoton connects-toSodium connects-toPlasma Cell connects-toElectron connects-toThyroid connects-toVitamin D connects-toAntibody connects-toNeuron connects-toPlatelet connects-toKidney connects-toNeutrophil connects-toReproductive System connects-toWaldenstrom Macroglobulinemia connects-toSpleen connects-toFibroblast connects-toInsulin connects-toEndothelial Cell connects-toMantle Cell Lymphoma connects-toStat3 connects-toAtherosclerosis connects-toVenous Thromboembolism connects-toMajor Depressive Disorder connects-toAnemia Of Chronic Disease connects-toStroke connects-toNeuropathic Pain connects-toOsteoporosis connects-toHeart Failure connects-toDigestive System connects-toIntegumentary System connects-toGeneralized Anxiety Disorder connects-toRenal System connects-toImmune System connects-toEndocrine System connects-toLymphatic System connects-toNervous System connects-toMusculoskeletal System connects-toRespiratory System connects-toCorticosteroids connects-toAdalimumab connects-toHepatic Lobule connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toPeripheral Nerve connects-toAnca Vasculitis connects-toArterial Wall connects-toCholangiocarcinoma connects-toGerminal Center connects-toImmune Thrombocytopenia connects-toIga Nephropathy connects-toAplastic Anemia connects-toCovid 19 Disease connects-toRig I connects-toPd 1 connects-toMyc connects-toPdgf connects-toTnf Alpha connects-toTert connects-toIfn Gamma connects-toPerforin connects-toCgas Sting connects-toBaff connects-toCollagen connects-toVegf connects-toIl 6 connects-toIl 10 connects-toNlrp3 Inflammasome connects-toAkt connects-toNf Kb connects-toNfe2L2 connects-toJak1 2 connects-toMyd88 connects-toSmad4 connects-toGalectin 3 connects-toEzh2 connects-toMtor connects-toFoxo connects-toHif 1Alpha connects-toCdk4 6 connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toPik3Ca connects-toAutophagy connects-toDnmt3A connects-toAmpk connects-toCcr5 connects-toSrc Kinase connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toCd20 connects-toMhc Class Ii connects-toHepcidin connects-toImmunoglobulin G connects-toHemoglobin connects-toIl 2 connects-toXanthine Oxidase connects-toNitric Oxide connects-toAdiponectin connects-toIl 4 connects-toIl 17A connects-toLeptin connects-toIl 13 connects-toZinc connects-toResistin connects-toB Cell connects-toIron connects-toMacrophage connects-toIl 12 connects-toIl 5 connects-toIge connects-toIl 23 connects-toRegulatory T Cell connects-toMast Cell connects-toComplement C5 connects-toC5Ar1 connects-toTransferrin connects-toFactor H connects-toC1 Esterase Inhibitor connects-toOsteopontin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toMagnesium connects-toIodine connects-toCopper connects-toPotassium connects-toCalcium connects-toChloride connects-toNitrogen connects-toPhosphorus connects-toCarbon connects-toHydrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr

Sources