Atlas One · Host Biology · Scale 07 — System

Mantle Cell Lymphoma

Mantle cell lymphoma is aggressive B-cell lymphoma with t(11;14) CCND1-IGH → cyclin D1 overexpression and CDK4/6 → S-phase entry; SOX11+, ATM deletion in ~40%, blastoid variant has TP53 mutations. Ibrutinib/zanubrutinib and venetoclax transformed R/R MCL; CAR-T is approved.

Also known as: mantle cell lymphoma, MCL, t(11;14) lymphoma, CCND1-IGH, cyclin D1 lymphoma, blastoid MCL, leukemic non-nodal MCL

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
mantle-cell-lymphoma

Mantle Cell Lymphoma

Mantle cell lymphoma is aggressive B-cell lymphoma with t(11;14) CCND1-IGH → cyclin D1 overexpression and CDK4/6 → S-phase entry; SOX11+, ATM deletion in ~40%, blastoid variant has TP53 mutations. Ibrutinib/zanubrutinib and venetoclax transformed R/R MCL; CAR-T is approved.

Entry Metadata

FieldValue
IDmantle-cell-lymphoma
NameMantle Cell Lymphoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCyclin D1 connects-toBcl 2 connects-toP53 connects-toAtm connects-toBtk connects-toNf Kb connects-toCll connects-toFollicular Lymphoma connects-toB Cell connects-toSmall Intestine connects-toLymphatic System connects-toSpleen connects-toDlbcl connects-toGerminal Center connects-toMultiple Myeloma connects-toHodgkin Lymphoma connects-toBurkitt Lymphoma connects-toBone Marrow connects-toRb1 connects-toCd20 connects-toDigestive System connects-toImmune System connects-toMtor connects-toWaldenstrom Macroglobulinemia connects-toT Cytotoxic Cell connects-toCdk4 6 connects-toLarge Intestine connects-toNatural Killer Cell connects-toCalcium connects-toBrain connects-toMacrophage connects-toIron connects-toLiver connects-toRegulatory T Cell connects-toPhoton connects-toPhosphorus connects-toStomach connects-toElectron connects-toEye connects-toPotassium connects-toAntibody connects-toErythrocyte connects-toPlatelet connects-toHepatitis B connects-toCardiomyocyte connects-toAkt connects-toIntestinal Epithelium connects-toFibroblast connects-toMds connects-toStat3 connects-toCytokine Storm connects-toVenous Thromboembolism connects-toSepsis connects-toPneumocystis Jirovecii connects-toAnemia Of Chronic Disease connects-toHepatitis B Virus connects-toAspergillus Fumigatus connects-toHeart Failure connects-toNeuropathic Pain connects-toVaricella Zoster Virus connects-toMajor Depressive Disorder connects-toCardiovascular System connects-toNervous System connects-toGeneralized Anxiety Disorder connects-toMusculoskeletal System connects-toRenal System connects-toRespiratory System connects-toIntegumentary System connects-toReproductive System connects-toEndocrine System connects-toTargeted Therapy connects-toCar T connects-toCancer Chemotherapy connects-toCardiac Conduction System connects-toAll connects-toCheckpoint Inhibitors connects-toMyocardium connects-toHepatic Lobule connects-toPtcl connects-toImmune Thrombocytopenia connects-toCovid 19 Disease connects-toGout connects-toNotch connects-toMyc connects-toEzh2 connects-toPik3Ca connects-toHif 1Alpha connects-toVegf connects-toCxcl12 connects-toTert connects-toCcl2 connects-toSrc Kinase connects-toCaspase 3 connects-toRad51 connects-toPerforin connects-toComplement C3 connects-toImmunoglobulin G connects-toE2F1 connects-toCdkn2A connects-toPten connects-toJak1 2 connects-toIl 6 connects-toMdm2 connects-toErk1 2 connects-toGalectin 3 connects-toTgf Beta connects-toStat1 connects-toSmad4 connects-toFoxo connects-toGsk 3B connects-toS100A8 A9 connects-toCgas Sting connects-toDnmt3A connects-toAutophagy connects-toArid1A connects-toAmpk connects-toCcr5 connects-toBaff connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toCalcineurin connects-toAdenosine connects-toOsteopontin connects-toMhc Class Ii connects-toIl 2 connects-toXanthine Oxidase connects-toTroponin Complex connects-toHemoglobin connects-toProton connects-toIl 10 connects-toIl 4 connects-toNitric Oxide connects-toSpleen connects-toT Cytotoxic Cell connects-toCalcium connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toNatural Killer Cell connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toTslp connects-toErythropoietin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toCarbon connects-toChloride connects-toNitrogen connects-toHydrogen connects-toOxygen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf

Sources