Atlas One · Host Biology · Scale 07 — System

Myelodysplastic Syndromes

Myelodysplastic syndromes are clonal hematopoietic disorders with cytopenias and dysplasia; SF3B1, DNMT3A, TET2, and TP53 mutations define subtypes. Azacitidine+venetoclax is higher-risk standard; luspatercept approved for SF3B1-mutant MDS; allo-SCT is the only cure.

Also known as: MDS, myelodysplastic syndrome, myelodysplasia, MDS-EB, refractory anemia, IPSS-R, azacitidine MDS, hypomethylating agent MDS, SF3B1 MDS, MDS-MPN

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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mds

Myelodysplastic Syndromes

Myelodysplastic syndromes are clonal hematopoietic disorders with cytopenias and dysplasia; SF3B1, DNMT3A, TET2, and TP53 mutations define subtypes. Azacitidine+venetoclax is higher-risk standard; luspatercept approved for SF3B1-mutant MDS; allo-SCT is the only cure.

Entry Metadata

FieldValue
IDmds
NameMyelodysplastic Syndromes
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toDnmt3A connects-toEzh2 connects-toP53 connects-toIdh2 connects-toActivin A connects-toBone Marrow connects-toAml connects-toErythrocyte connects-toMyelofibrosis connects-toAplastic Anemia connects-toNeutrophil

Sources