Atlas One · Host Biology · Scale 07 — System

Myelodysplastic Syndromes

Myelodysplastic syndromes are clonal hematopoietic disorders with cytopenias and dysplasia; SF3B1, DNMT3A, TET2, and TP53 mutations define subtypes. Azacitidine+venetoclax is higher-risk standard; luspatercept approved for SF3B1-mutant MDS; allo-SCT is the only cure.

Also known as: MDS, myelodysplastic syndrome, myelodysplasia, MDS-EB, refractory anemia, IPSS-R, azacitidine MDS, hypomethylating agent MDS, SF3B1 MDS, MDS-MPN

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
mds

Myelodysplastic Syndromes

Myelodysplastic syndromes are clonal hematopoietic disorders with cytopenias and dysplasia; SF3B1, DNMT3A, TET2, and TP53 mutations define subtypes. Azacitidine+venetoclax is higher-risk standard; luspatercept approved for SF3B1-mutant MDS; allo-SCT is the only cure.

Entry Metadata

FieldValue
IDmds
NameMyelodysplastic Syndromes
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toDnmt3A connects-toEzh2 connects-toP53 connects-toIdh2 connects-toActivin A connects-toBone Marrow connects-toAml connects-toErythrocyte connects-toMyelofibrosis connects-toAplastic Anemia connects-toNeutrophil connects-toCmml connects-toPhoton connects-toPlatelet connects-toMyeloproliferative Neoplasms connects-toLi Fraumeni Syndrome connects-toIron Deficiency Anemia connects-toSf3B1 connects-toErythropoietin connects-toImmune System connects-toLiver connects-toSpleen connects-toAnemia Of Chronic Disease connects-toIron connects-toTet2 connects-toT Cytotoxic Cell connects-toNlrp3 Inflammasome connects-toCaspase 3 connects-toMacrophage connects-toHeart connects-toOxygen connects-toRegulatory T Cell connects-toCopper connects-toSkin connects-toFibrosis connects-toElectron connects-toZinc connects-toHepatocyte connects-toPancreas connects-toAntibody connects-toLung connects-toIdh1 connects-toThyroid connects-toReproductive System connects-toRunx1 connects-toPnh connects-toNatural Killer Cell connects-toTgf Beta connects-toOsteoblast connects-toCardiovascular System connects-toNf Kb connects-toStat3 connects-toSepsis connects-toAspergillus Fumigatus connects-toCandida Albicans connects-toHeart Failure connects-toPneumocystis Jirovecii connects-toVenous Thromboembolism connects-toMajor Depressive Disorder connects-toEndocrine System connects-toVaricella Zoster Virus connects-toGeneralized Anxiety Disorder connects-toIntegumentary System connects-toMusculoskeletal System connects-toDigestive System connects-toNervous System connects-toRespiratory System connects-toLymphatic System connects-toRenal System connects-toTargeted Therapy connects-toHerpesvirus connects-toCancer Chemotherapy connects-toMyocardium connects-toThalassemia connects-toHepatic Lobule connects-toMultiple Myeloma connects-toUveal Melanoma connects-toBreast Cancer connects-toAnca Vasculitis connects-toCardiac Conduction System connects-toAtherosclerosis connects-toIdh Mutant Glioma connects-toType 2 Diabetes connects-toTnf Alpha connects-toFlt3 connects-toAkt connects-toSrsf2 connects-toS100A8 A9 connects-toThrombopoietin connects-toIl 1B connects-toHepcidin connects-toIfn Gamma connects-toBcl 2 connects-toMdm2 connects-toCxcl12 connects-toTlr4 connects-toSmad4 connects-toIl 6 connects-toMyd88 connects-toMtor connects-toKras connects-toJak1 2 connects-toPten connects-toCgas Sting connects-toGalectin 3 connects-toStat1 connects-toErk1 2 connects-toFoxo connects-toHif 1Alpha connects-toGsk 3B connects-toPerforin connects-toCdk4 6 connects-toSrc Kinase connects-toPik3Ca connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toMhc Class Ii connects-toVegf connects-toCalr connects-toHemoglobin connects-toIl 2 connects-toAngiopoietin connects-toFerroportin connects-toXanthine Oxidase connects-toIl 10 connects-toIl 4 connects-toAdiponectin connects-toLeptin connects-toIl 13 connects-toResistin connects-toZinc connects-toType I Interferon connects-toMyeloproliferative Neoplasms connects-toMacrophage connects-toDendritic Cell connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toPlasma Cell connects-toT Helper Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toTransferrin connects-toOsteopontin connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCalcium connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toNitrogen connects-toChloride connects-toHydrogen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf

Sources