Atlas One · Host Biology · Scale 03 — Molecular

RUNX1

RUNX1 (AML1) is a core binding factor transcription factor essential for hematopoiesis; ETV6-RUNX1 t(12;21) defines ~25% of pediatric B-ALL (favorable); RUNX1-RUNX1T1 t(8;21) defines CBF-AML (favorable); somatic RUNX1 mutations (~15% AML) and germline RUNX1 → FPD-AML.

Also known as: RUNX1, AML1, CBFA2, core binding factor, ETV6-RUNX1, TEL-AML1, RUNX1-RUNX1T1, AML1-ETO, t(8;21) AML, t(12;21) ALL, familial platelet disorder, FPD-AML, CBF-AML

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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runx1

RUNX1

RUNX1 (AML1) is a core binding factor transcription factor essential for hematopoiesis; ETV6-RUNX1 t(12;21) defines ~25% of pediatric B-ALL (favorable); RUNX1-RUNX1T1 t(8;21) defines CBF-AML (favorable); somatic RUNX1 mutations (~15% AML) and germline RUNX1 → FPD-AML.

Entry Metadata

FieldValue
IDrunx1
NameRUNX1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toBcl 2 connects-toNotch connects-toFlt3 connects-toPd 1

Sources