Atlas One · Host Biology · Scale 03 — Molecular

NOTCH

Juxtacrine pathway: Jagged/DLL ligands → NICD nuclear translocation → HES/HEY transcription → cell fate decisions. NOTCH1 gain-of-function mutations drive >60% of T-ALL and triple-negative breast cancer; gamma-secretase inhibitors block NOTCH processing.

Also known as: Notch signaling, NOTCH1, NOTCH2, NOTCH3, NOTCH4, HES1, NICD, Delta-like ligand, Jagged, DLL, CSL, RBPJ, gamma-secretase

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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notch

NOTCH

Juxtacrine pathway: Jagged/DLL ligands → NICD nuclear translocation → HES/HEY transcription → cell fate decisions. NOTCH1 gain-of-function mutations drive >60% of T-ALL and triple-negative breast cancer; gamma-secretase inhibitors block NOTCH processing.

Entry Metadata

FieldValue
IDnotch
NameNOTCH
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toWnt Beta Catenin connects-toMyc connects-toP53 connects-toKras connects-toCyclin D1 connects-toHif 1Alpha connects-toMtor

Sources