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myc
MYC
bHLH-LZ transcription factor; master oncogene amplified or overexpressed in >50% of cancers. Drives ribosome biogenesis and cell cycle entry via E-box/MAX binding. Protein-level targeting is difficult; BET bromodomain inhibitors (JQ1) suppress MYC transcription indirectly.
Entry Metadata
| Field | Value |
|---|---|
| ID | myc |
| Name | MYC |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Dang CV. MYC on the path to cancer. Cell. 2012;149(1):22-35. · PubMed 22464321
- Stine ZE, Walton ZE, Altman BJ, Hsieh AL, Dang CV. MYC, metabolism, and cancer. Cancer Discov. 2015;5(10):1024-1039. · PubMed 26382145
- Filippakopoulos P, Qi J, Picaud S, et al. Selective inhibition of BET bromodomains. Nature. 2010;468(7327):1067-1073. · PubMed 20871596