Atlas One · Host Biology · Scale 03 — Molecular

KRAS

Small GTPase and proto-oncogene; mutated in ~25% of all human cancers (PDAC ~90%, CRC ~45%, NSCLC ~30%). Oncogenic mutations (G12D, G12V, G12C) lock KRAS in GTP-bound active state, constitutively activating RAF-MEK-ERK and PI3K-Akt-mTOR. KRAS G12C now targetable by sotorasib.

Also known as: KRAS4A, KRAS4B, Kirsten RAS, RAS GTPase, v-Ki-ras2

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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kras

KRAS

Small GTPase and proto-oncogene; mutated in ~25% of all human cancers (PDAC ~90%, CRC ~45%, NSCLC ~30%). Oncogenic mutations (G12D, G12V, G12C) lock KRAS in GTP-bound active state, constitutively activating RAF-MEK-ERK and PI3K-Akt-mTOR. KRAS G12C now targetable by sotorasib.

Entry Metadata

FieldValue
IDkras
NameKRAS
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toNf Kb connects-toMtor connects-toTgf Beta connects-toPancreatic Cancer connects-toNsclc connects-toColorectal Cancer

Sources