Atlas One · Host Biology · Scale 07 — System

Pancreatic Cancer

Aggressive exocrine malignancy; KRAS mutations in >90%, TP53 in ~75%, CDKN2A and SMAD4 in ~50%; desmoplastic stroma limits drug delivery. FOLFIRINOX and gemcitabine+nab-paclitaxel are standards; KRAS inhibitors (sotorasib for G12C) and BRCA-mutant PARP inhibitors are active.

Also known as: PDAC, pancreatic ductal adenocarcinoma, pancreatic adenocarcinoma, exocrine pancreatic cancer, metastatic PDAC, borderline resectable pancreatic cancer

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
pancreatic-cancer

Pancreatic Cancer

Aggressive exocrine malignancy; KRAS mutations in >90%, TP53 in ~75%, CDKN2A and SMAD4 in ~50%; desmoplastic stroma limits drug delivery. FOLFIRINOX and gemcitabine+nab-paclitaxel are standards; KRAS inhibitors (sotorasib for G12C) and BRCA-mutant PARP inhibitors are active.

Entry Metadata

FieldValue
IDpancreatic-cancer
NamePancreatic Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toKras connects-toTgf Beta connects-toBrca1 connects-toEgfr connects-toCdkn2A connects-toP53 connects-toSmad4 connects-toPancreas connects-toFibroblast connects-toHereditary Pancreatitis connects-toType 2 Diabetes connects-toVenous Thromboembolism connects-toPeutz Jeghers Syndrome connects-toLi Fraumeni Syndrome connects-toPhoton connects-toNeuroendocrine Tumors connects-toBrca2 connects-toInsulin connects-toLiver connects-toVegf connects-toDigestive System connects-toImmune System connects-toCollagen connects-toT Cytotoxic Cell connects-toLynch Syndrome connects-toAutophagy connects-toMacrophage connects-toRegulatory T Cell connects-toOxygen connects-toFibrosis connects-toSmall Intestine connects-toCarbon connects-toSpleen connects-toPlatelet connects-toPeripheral Nerve connects-toStomach connects-toLung connects-toNeuron connects-toAlbumin connects-toMagnesium connects-toAntibody connects-toGlucagon connects-toNeutrophil connects-toAdipocyte connects-toMajor Depressive Disorder connects-toMelanoma connects-toPalb2 connects-toCxcl12 connects-toObesity connects-toNeuropathic Pain connects-toSepsis connects-toStat3 connects-toNf Kb connects-toDisseminated Intravascular Coagulation connects-toAnemia Of Chronic Disease connects-toOsteoporosis connects-toCkd connects-toHeart Failure connects-toHereditary Breast Ovarian Cancer connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toEndocrine System connects-toNervous System connects-toRespiratory System connects-toLymphatic System connects-toIntegumentary System connects-toCardiovascular System connects-toTargeted Therapy connects-toMusculoskeletal System connects-toRenal System connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toIslet Of Langerhans connects-toGerminal Center connects-toCholangiocarcinoma connects-toColorectal Cancer connects-toHepatic Lobule connects-toGastric Cancer connects-toIntestinal Epithelium connects-toArterial Wall connects-toStroke connects-toCystic Fibrosis connects-toMyc connects-toHif 1Alpha connects-toNtrk connects-toAkt connects-toCyclin D1 connects-toEzh2 connects-toCcl2 connects-toIl 6 connects-toSmo connects-toAtm connects-toPrss1 connects-toCaspase 3 connects-toNotch connects-toAxl Receptor connects-toPdgf connects-toErk1 2 connects-toMtor connects-toE2F1 connects-toJak1 2 connects-toNfe2L2 connects-toMyd88 connects-toGalectin 3 connects-toPten connects-toCgas Sting connects-toStat1 connects-toCdk4 6 connects-toFoxo connects-toPerforin connects-toMdm2 connects-toS100A8 A9 connects-toGsk 3B connects-toPik3Ca connects-toSrc Kinase connects-toAmpk connects-toCcr5 connects-toDnmt3A connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toActivin A connects-toMhc Class Ii connects-toCftr connects-toMu Opioid Receptor connects-toIl 2 connects-toHemoglobin connects-toIl 10 connects-toXanthine Oxidase connects-toProton connects-toProstaglandins connects-toIl 4 connects-toIron connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toHepcidin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toNatural Killer Cell connects-toIl 23 connects-toIge connects-toMast Cell connects-toC5Ar1 connects-toVitamin D connects-toB Cell connects-toComplement C5 connects-toFactor H connects-toTslp connects-toPeriostin connects-toErythropoietin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toCalcium connects-toCopper connects-toPotassium connects-toChloride connects-toHydrogen connects-toNitrogen connects-toPhosphorus connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine

Sources