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brca2
BRCA2
Tumor suppressor; BRCA2-PALB2 complex loads RAD51 onto RPA-coated ssDNA → homologous recombination repair; BRCA2 loss → HRD → PARP inhibitor synthetic lethality. Germline BRCA2 mutations → breast (~50-70% LT risk), ovarian (~10-30%), prostate, and pancreatic cancer risk.
Entry Metadata
| Field | Value |
|---|---|
| ID | brca2 |
| Name | BRCA2 |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Wooster R, Bignell G, Lancaster J, et al. Identification of the breast cancer susceptibility gene BRCA2. Nature. 1995;378(6559):789-792. · PubMed 8524414
- Moore K, Colombo N, Scambia G, et al. Maintenance olaparib in patients with newly diagnosed advanced ovarian cancer. N Engl J Med. 2018;379(26):2495-2505. · PubMed 30345884