PTEN

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pten

Lipid phosphatase tumor suppressor; dephosphorylates PIP3 to PIP2, opposing PI3K-AKT-mTOR. Second most frequently mutated after p53. Loss drives endometrial, GBM, prostate, and breast cancers; creates synthetic lethality with PARP inhibitors and mTOR inhibitors.

Entry Metadata

Field	Value
ID	pten
Name	PTEN
Status	draft
Last reviewed	2026-06-06
Atlas	01-human
Scale	03-molecular

Cross-Atlas Connections

connects-toPik3Ca connects-toAkt connects-toP53 connects-toMtor

Sources

Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997;275(5308):1943-1947. · PubMed 9072974
Stambolic V, Suzuki A, de la Pompa JL, et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 1998;95(1):29-39. · PubMed 9778245
Milella M, Falcone I, Conciatori F, et al. PTEN: multiple functions in human malignant tumors. Front Oncol. 2015;5:24. · PubMed 25763356